Cellular gene induction during herpes simplex virus infection can occur without viral protein synthesis

L. M. Kemp; C. M. Preston; V. G. Preston; D. S. Latchman

doi:10.1093/nar/14.23.9261

Cellular gene induction during herpes simplex virus infection can occur without viral protein synthesis

L. M. Kemp, C. M. Preston, V. G. Preston, D. S. Latchman

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Infection of cultured cells with herpes simplem virus (HSV) results in the transcriptional induction of a small number of cellular genes. Although the majority of such genes are dependent upon viral protein synthesis for their induction, a small minority are not. These genes are induced by events occuring prior to the onset or viral protein synthesis, in particular by binding of the virus to the cell surface and cellular entry of the virion. The significance of such cellular gene induction early in viral infection is discussed in terms of virus-cell interaction in general and the mechanism of transformation by HSV in particular.

Original language	English
Pages (from-to)	9261-9270
Number of pages	10
Journal	Nucleic Acids Research
Volume	14
Issue number	23
DOIs	https://doi.org/10.1093/nar/14.23.9261
Publication status	Published - 9 Dec 1986
Externally published	Yes

Access to Document

10.1093/nar/14.23.9261

Cite this

@article{7f9425651fec4f33bbb73b15f01fede1,

title = "Cellular gene induction during herpes simplex virus infection can occur without viral protein synthesis",

abstract = "Infection of cultured cells with herpes simplem virus (HSV) results in the transcriptional induction of a small number of cellular genes. Although the majority of such genes are dependent upon viral protein synthesis for their induction, a small minority are not. These genes are induced by events occuring prior to the onset or viral protein synthesis, in particular by binding of the virus to the cell surface and cellular entry of the virion. The significance of such cellular gene induction early in viral infection is discussed in terms of virus-cell interaction in general and the mechanism of transformation by HSV in particular.",

author = "Kemp, {L. M.} and Preston, {C. M.} and Preston, {V. G.} and Latchman, {D. S.}",

year = "1986",

month = dec,

day = "9",

doi = "10.1093/nar/14.23.9261",

language = "English",

volume = "14",

pages = "9261--9270",

journal = "Nucleic Acids Research",

issn = "0305-1048",

publisher = "Oxford University Press",

number = "23",

}

TY - JOUR

T1 - Cellular gene induction during herpes simplex virus infection can occur without viral protein synthesis

AU - Kemp, L. M.

AU - Preston, C. M.

AU - Preston, V. G.

AU - Latchman, D. S.

PY - 1986/12/9

Y1 - 1986/12/9

N2 - Infection of cultured cells with herpes simplem virus (HSV) results in the transcriptional induction of a small number of cellular genes. Although the majority of such genes are dependent upon viral protein synthesis for their induction, a small minority are not. These genes are induced by events occuring prior to the onset or viral protein synthesis, in particular by binding of the virus to the cell surface and cellular entry of the virion. The significance of such cellular gene induction early in viral infection is discussed in terms of virus-cell interaction in general and the mechanism of transformation by HSV in particular.

AB - Infection of cultured cells with herpes simplem virus (HSV) results in the transcriptional induction of a small number of cellular genes. Although the majority of such genes are dependent upon viral protein synthesis for their induction, a small minority are not. These genes are induced by events occuring prior to the onset or viral protein synthesis, in particular by binding of the virus to the cell surface and cellular entry of the virion. The significance of such cellular gene induction early in viral infection is discussed in terms of virus-cell interaction in general and the mechanism of transformation by HSV in particular.

UR - http://www.scopus.com/inward/record.url?scp=0022826965&partnerID=8YFLogxK

U2 - 10.1093/nar/14.23.9261

DO - 10.1093/nar/14.23.9261

M3 - Article

C2 - 3797240

AN - SCOPUS:0022826965

SN - 0305-1048

VL - 14

SP - 9261

EP - 9270

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - 23

ER -

Cellular gene induction during herpes simplex virus infection can occur without viral protein synthesis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this