Central airway squamous metaplasia following radiation therapy mimicking local tumour recurrence

Jonathan Arulanantham; Revadhi Chelvarajah; A. Kasim Ismail; Victoria J. Bray; Shalini K. Vinod; Jonathan P. Williamson

doi:10.1016/j.rmcr.2023.101942

Central airway squamous metaplasia following radiation therapy mimicking local tumour recurrence

Jonathan Arulanantham
, Revadhi Chelvarajah
, A. Kasim Ismail
, Victoria J. Bray
, Shalini K. Vinod
, Jonathan P. Williamson

Macquarie University
Northern Health
Liverpool Hospital
SWSLHD
University of New South Wales

Research output: Contribution to journal › Article › peer-review

Abstract

Radiation therapy can result in injury to the lung parenchyma and central airways; the latter is less well documented in the literature. Here, we describe a 65-year-old Caucasian male, who developed focal endobronchial nodules and right main bronchial stenosis suggesting tumour recurrence, 32 months following curative intent concurrent chemoradiation therapy for Stage 3B squamous cell carcinoma of the lung. Computed tomography and positron emission tomography results are detailed. Flexible bronchoscopy with bronchial biopsies revealed squamous metaplasia rather than malignant tumour recurrence, with ongoing observation planned.

Original language	English
Article number	101942
Journal	Respiratory Medicine Case Reports
Volume	46
DOIs	https://doi.org/10.1016/j.rmcr.2023.101942
Publication status	Published - Jan 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 The Authors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chemoradiation therapy
COPD
Non-small cell lung cancer
Respiratory structure and function
Smoking
Squamous Metaplasia

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10.1016/j.rmcr.2023.101942

Cite this

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title = "Central airway squamous metaplasia following radiation therapy mimicking local tumour recurrence",

abstract = "Radiation therapy can result in injury to the lung parenchyma and central airways; the latter is less well documented in the literature. Here, we describe a 65-year-old Caucasian male, who developed focal endobronchial nodules and right main bronchial stenosis suggesting tumour recurrence, 32 months following curative intent concurrent chemoradiation therapy for Stage 3B squamous cell carcinoma of the lung. Computed tomography and positron emission tomography results are detailed. Flexible bronchoscopy with bronchial biopsies revealed squamous metaplasia rather than malignant tumour recurrence, with ongoing observation planned.",

keywords = "Chemoradiation therapy, COPD, Non-small cell lung cancer, Respiratory structure and function, Smoking, Squamous Metaplasia",

author = "Jonathan Arulanantham and Revadhi Chelvarajah and Ismail, \{A. Kasim\} and Bray, \{Victoria J.\} and Vinod, \{Shalini K.\} and Williamson, \{Jonathan P.\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = jan,

doi = "10.1016/j.rmcr.2023.101942",

language = "English",

volume = "46",

journal = "Respiratory Medicine Case Reports",

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TY - JOUR

T1 - Central airway squamous metaplasia following radiation therapy mimicking local tumour recurrence

AU - Arulanantham, Jonathan

AU - Chelvarajah, Revadhi

AU - Ismail, A. Kasim

AU - Bray, Victoria J.

AU - Vinod, Shalini K.

AU - Williamson, Jonathan P.

PY - 2023/1

Y1 - 2023/1

N2 - Radiation therapy can result in injury to the lung parenchyma and central airways; the latter is less well documented in the literature. Here, we describe a 65-year-old Caucasian male, who developed focal endobronchial nodules and right main bronchial stenosis suggesting tumour recurrence, 32 months following curative intent concurrent chemoradiation therapy for Stage 3B squamous cell carcinoma of the lung. Computed tomography and positron emission tomography results are detailed. Flexible bronchoscopy with bronchial biopsies revealed squamous metaplasia rather than malignant tumour recurrence, with ongoing observation planned.

AB - Radiation therapy can result in injury to the lung parenchyma and central airways; the latter is less well documented in the literature. Here, we describe a 65-year-old Caucasian male, who developed focal endobronchial nodules and right main bronchial stenosis suggesting tumour recurrence, 32 months following curative intent concurrent chemoradiation therapy for Stage 3B squamous cell carcinoma of the lung. Computed tomography and positron emission tomography results are detailed. Flexible bronchoscopy with bronchial biopsies revealed squamous metaplasia rather than malignant tumour recurrence, with ongoing observation planned.

KW - Chemoradiation therapy

KW - COPD

KW - Non-small cell lung cancer

KW - Respiratory structure and function

KW - Smoking

KW - Squamous Metaplasia

UR - https://www.scopus.com/pages/publications/85175622355

U2 - 10.1016/j.rmcr.2023.101942

DO - 10.1016/j.rmcr.2023.101942

M3 - Article

AN - SCOPUS:85175622355

SN - 2213-0071

VL - 46

JO - Respiratory Medicine Case Reports

JF - Respiratory Medicine Case Reports

M1 - 101942

ER -

Central airway squamous metaplasia following radiation therapy mimicking local tumour recurrence

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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