Change in sympathetic nerve firing pattern associated with dietary weight loss in the metabolic syndrome

Elisabeth Lambert; Nora E. Straznicky; Tye Dawood; Carolina Ika-Sari; Mariee Grima; Murray D. Esler; Markus P. Schlaich; Gavin W. Lambert

doi:10.3389/fphys.2011.00052

Change in sympathetic nerve firing pattern associated with dietary weight loss in the metabolic syndrome

Elisabeth Lambert, Nora E. Straznicky, Tye Dawood, Carolina Ika-Sari, Mariee Grima, Murray D. Esler, Markus P. Schlaich, Gavin W. Lambert

Research output: Contribution to journal › Article › peer-review

Abstract

Sympathetic activation in subjects with the metabolic syndrome (MS) plays a role in the pathogenesis of cardiovascular disease development. Diet-induced weight loss decreases sympathetic outflow. However the mechanisms that account for sympathetic inhibition are not known. We sought to provide a detailed description of the sympathetic response to diet by analyzing the firing behavior of single-unit sympathetic nerve fibers. Fourteen subjects (57 Â±2 years, nine men, five females) fulfilling ATP III criteria for the MS underwent a 3-month low calorie diet. Metabolic profile, hemodynamic parameters, and multi-unit and single-unit muscle sympathetic nerve activity (MSNA, microneurography) were assessed prior to and at the end of the diet. Patients' weight dropped from 96 Â±4 to 88 Â±3 kg (P< 0.001). This was associated with a decrease in systolic and diastolic blood pressure (-12 Â±3 and -5Â±2mmHg, P<0.05), and in heart rate (-7Â±2bpm, P<0.01) and an improvement in all metabolic parameters (fasting glucose: -0.302.1 Â± 0.118 mmol/l, total cholesterol: -0.564 Â±0.164 mmol/l, triglycerides: -0.414Â±0.137 mmol/l, P<0.05). Multi-unit MSNA decreased from 68Â±4 to 59 Â±5 bursts/100 heartbeats (P<0.05). Single-unit MSNA indicated that the firing rate of individual vasoconstrictor fibers decreased from 59 Â± 10 to 32 Â± 4 spikes/100 heart beats (P < 0.05).The probability of firing decreased from 34 Â± 5 to 23 Â± 3% of heartbeats (P < 0.05), and the incidence of multiple firing decreased from 14 Â±4 to 6Â± 1 % of heartbeats (P < 0.05). Cardiac and sympathetic baroref lex function were significantly improved (cardiac slope: 6.57 Â± 0.69 to 9.57 Â± 1.20 ms-mmHg~1; sympathetic slope: -3.86 Â± 0.34 to -5.05 Â± 0.47 bursts/100 heartbeats-mmHg"1, P < 0.05 for both). Hypocaloric diet decreased sympathetic activity and improved hemodynamic and metabolic parameters.The sympathoinhibition associated with weight loss involves marked changes, not only in the rate but also in the firing pattern of active vasoconstrictive fibers.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Frontiers in Physiology
Volume	2
DOIs	https://doi.org/10.3389/fphys.2011.00052
Publication status	Published - 2011

Open Access - Access Right Statement

Copyright © 2011 Lambert, Straznicky, Dawood, Ika-Sari, Grima, Esler, Schlaich and Lambert. This is an open-access article subject to a nonexclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

Keywords

diet
metabolic syndrome
obesity
sympathetic nervous system
weight loss

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fphys.2011.00052

Cite this

@article{f579fc8c8ac0412096a33e0d5f6fd65b,

title = "Change in sympathetic nerve firing pattern associated with dietary weight loss in the metabolic syndrome",

abstract = "Sympathetic activation in subjects with the metabolic syndrome (MS) plays a role in the pathogenesis of cardiovascular disease development. Diet-induced weight loss decreases sympathetic outflow. However the mechanisms that account for sympathetic inhibition are not known. We sought to provide a detailed description of the sympathetic response to diet by analyzing the firing behavior of single-unit sympathetic nerve fibers. Fourteen subjects (57 {\^A}±2 years, nine men, five females) fulfilling ATP III criteria for the MS underwent a 3-month low calorie diet. Metabolic profile, hemodynamic parameters, and multi-unit and single-unit muscle sympathetic nerve activity (MSNA, microneurography) were assessed prior to and at the end of the diet. Patients' weight dropped from 96 {\^A}±4 to 88 {\^A}±3 kg (P< 0.001). This was associated with a decrease in systolic and diastolic blood pressure (-12 {\^A}±3 and -5{\^A}±2mmHg, P<0.05), and in heart rate (-7{\^A}±2bpm, P<0.01) and an improvement in all metabolic parameters (fasting glucose: -0.302.1 {\^A}± 0.118 mmol/l, total cholesterol: -0.564 {\^A}±0.164 mmol/l, triglycerides: -0.414{\^A}±0.137 mmol/l, P<0.05). Multi-unit MSNA decreased from 68{\^A}±4 to 59 {\^A}±5 bursts/100 heartbeats (P<0.05). Single-unit MSNA indicated that the firing rate of individual vasoconstrictor fibers decreased from 59 {\^A}± 10 to 32 {\^A}± 4 spikes/100 heart beats (P < 0.05).The probability of firing decreased from 34 {\^A}± 5 to 23 {\^A}± 3% of heartbeats (P < 0.05), and the incidence of multiple firing decreased from 14 {\^A}±4 to 6{\^A}± 1 % of heartbeats (P < 0.05). Cardiac and sympathetic baroref lex function were significantly improved (cardiac slope: 6.57 {\^A}± 0.69 to 9.57 {\^A}± 1.20 ms-mmHg~1; sympathetic slope: -3.86 {\^A}± 0.34 to -5.05 {\^A}± 0.47 bursts/100 heartbeats-mmHg{"}1, P < 0.05 for both). Hypocaloric diet decreased sympathetic activity and improved hemodynamic and metabolic parameters.The sympathoinhibition associated with weight loss involves marked changes, not only in the rate but also in the firing pattern of active vasoconstrictive fibers.",

keywords = "diet, metabolic syndrome, obesity, sympathetic nervous system, weight loss",

author = "Elisabeth Lambert and Straznicky, {Nora E.} and Tye Dawood and Carolina Ika-Sari and Mariee Grima and Esler, {Murray D.} and Schlaich, {Markus P.} and Lambert, {Gavin W.}",

year = "2011",

doi = "10.3389/fphys.2011.00052",

language = "English",

volume = "2",

pages = "1--7",

journal = "Frontiers in Physiology",

issn = "1664-042X",

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TY - JOUR

T1 - Change in sympathetic nerve firing pattern associated with dietary weight loss in the metabolic syndrome

AU - Lambert, Elisabeth

AU - Straznicky, Nora E.

AU - Dawood, Tye

AU - Ika-Sari, Carolina

AU - Grima, Mariee

AU - Esler, Murray D.

AU - Schlaich, Markus P.

AU - Lambert, Gavin W.

PY - 2011

Y1 - 2011

N2 - Sympathetic activation in subjects with the metabolic syndrome (MS) plays a role in the pathogenesis of cardiovascular disease development. Diet-induced weight loss decreases sympathetic outflow. However the mechanisms that account for sympathetic inhibition are not known. We sought to provide a detailed description of the sympathetic response to diet by analyzing the firing behavior of single-unit sympathetic nerve fibers. Fourteen subjects (57 Â±2 years, nine men, five females) fulfilling ATP III criteria for the MS underwent a 3-month low calorie diet. Metabolic profile, hemodynamic parameters, and multi-unit and single-unit muscle sympathetic nerve activity (MSNA, microneurography) were assessed prior to and at the end of the diet. Patients' weight dropped from 96 Â±4 to 88 Â±3 kg (P< 0.001). This was associated with a decrease in systolic and diastolic blood pressure (-12 Â±3 and -5Â±2mmHg, P<0.05), and in heart rate (-7Â±2bpm, P<0.01) and an improvement in all metabolic parameters (fasting glucose: -0.302.1 Â± 0.118 mmol/l, total cholesterol: -0.564 Â±0.164 mmol/l, triglycerides: -0.414Â±0.137 mmol/l, P<0.05). Multi-unit MSNA decreased from 68Â±4 to 59 Â±5 bursts/100 heartbeats (P<0.05). Single-unit MSNA indicated that the firing rate of individual vasoconstrictor fibers decreased from 59 Â± 10 to 32 Â± 4 spikes/100 heart beats (P < 0.05).The probability of firing decreased from 34 Â± 5 to 23 Â± 3% of heartbeats (P < 0.05), and the incidence of multiple firing decreased from 14 Â±4 to 6Â± 1 % of heartbeats (P < 0.05). Cardiac and sympathetic baroref lex function were significantly improved (cardiac slope: 6.57 Â± 0.69 to 9.57 Â± 1.20 ms-mmHg~1; sympathetic slope: -3.86 Â± 0.34 to -5.05 Â± 0.47 bursts/100 heartbeats-mmHg"1, P < 0.05 for both). Hypocaloric diet decreased sympathetic activity and improved hemodynamic and metabolic parameters.The sympathoinhibition associated with weight loss involves marked changes, not only in the rate but also in the firing pattern of active vasoconstrictive fibers.

AB - Sympathetic activation in subjects with the metabolic syndrome (MS) plays a role in the pathogenesis of cardiovascular disease development. Diet-induced weight loss decreases sympathetic outflow. However the mechanisms that account for sympathetic inhibition are not known. We sought to provide a detailed description of the sympathetic response to diet by analyzing the firing behavior of single-unit sympathetic nerve fibers. Fourteen subjects (57 Â±2 years, nine men, five females) fulfilling ATP III criteria for the MS underwent a 3-month low calorie diet. Metabolic profile, hemodynamic parameters, and multi-unit and single-unit muscle sympathetic nerve activity (MSNA, microneurography) were assessed prior to and at the end of the diet. Patients' weight dropped from 96 Â±4 to 88 Â±3 kg (P< 0.001). This was associated with a decrease in systolic and diastolic blood pressure (-12 Â±3 and -5Â±2mmHg, P<0.05), and in heart rate (-7Â±2bpm, P<0.01) and an improvement in all metabolic parameters (fasting glucose: -0.302.1 Â± 0.118 mmol/l, total cholesterol: -0.564 Â±0.164 mmol/l, triglycerides: -0.414Â±0.137 mmol/l, P<0.05). Multi-unit MSNA decreased from 68Â±4 to 59 Â±5 bursts/100 heartbeats (P<0.05). Single-unit MSNA indicated that the firing rate of individual vasoconstrictor fibers decreased from 59 Â± 10 to 32 Â± 4 spikes/100 heart beats (P < 0.05).The probability of firing decreased from 34 Â± 5 to 23 Â± 3% of heartbeats (P < 0.05), and the incidence of multiple firing decreased from 14 Â±4 to 6Â± 1 % of heartbeats (P < 0.05). Cardiac and sympathetic baroref lex function were significantly improved (cardiac slope: 6.57 Â± 0.69 to 9.57 Â± 1.20 ms-mmHg~1; sympathetic slope: -3.86 Â± 0.34 to -5.05 Â± 0.47 bursts/100 heartbeats-mmHg"1, P < 0.05 for both). Hypocaloric diet decreased sympathetic activity and improved hemodynamic and metabolic parameters.The sympathoinhibition associated with weight loss involves marked changes, not only in the rate but also in the firing pattern of active vasoconstrictive fibers.

KW - diet

KW - metabolic syndrome

KW - obesity

KW - sympathetic nervous system

KW - weight loss

UR - http://handle.uws.edu.au:8081/1959.7/526867

U2 - 10.3389/fphys.2011.00052

DO - 10.3389/fphys.2011.00052

M3 - Article

SN - 1664-042X

VL - 2

SP - 1

EP - 7

JO - Frontiers in Physiology

JF - Frontiers in Physiology

ER -

Change in sympathetic nerve firing pattern associated with dietary weight loss in the metabolic syndrome

Abstract

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Keywords

UN SDGs

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