Chaperoning the immunosuppressant mycophenolic acid through the gastrointestinal tract : a role for copper

Alison C. Badrick, Graeme R. Hanson, Christopher E. Jones

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Mycophenolic acid (MPA) is a frontline immunosuppressant that limits rejection of transplanted organs. Optimal use of this drug is hampered by gastrointestinal adverse events that are thought to be triggered during the absorption phase. These events have a negative impact on graft and patient survival. Previous work has suggested that similar gastrointestinal adverse events observed with non-steroidal antiinflammatory use can be limited by delivering the drug as a copper complex. We have recently shown that MPA is able to bind copper ions to form [Cu(MPA)2(H2O)2]. We report here that this complex is retained in a solvent that mimics the low pH, high salt environment of the upper gastrointestinal tract, suggesting that copper chelation may be a useful way to modulate and control MPA absorption. In an organic solvent, the complex can be modified using the physiologically relevant ligand imidazole to form [CuMPA(imid)3], however this complex is not retained in low pH conditions.
    Original languageEnglish
    Pages (from-to)231-236
    Number of pages6
    JournalApplied Magnetic Resonance
    Volume36
    Issue number45384
    DOIs
    Publication statusPublished - 2009

    Keywords

    • copper
    • mycophenolic acid

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