TY - JOUR
T1 - Childhood environmental and genetic predictors of adulthood obesity : the cardiovascular risk in Young Finns Study
AU - Juonala, Markus
AU - Juhola, Jonna
AU - Magnussen, Costan G.
AU - Würtz, Peter
AU - Viikari, Jorma S. A.
AU - Thomson, Russell
AU - Seppälä, Ilkka
AU - Hernesniemi, Jussi
AU - Kähönen, Mika
AU - Lehtimaki, Terho
AU - Hurme, Mikko
AU - Telama, Risto
AU - Mikkila, Vera
AU - Eklund, Carita
AU - Rasanen, Leena
AU - Hintsanen, Mirka
AU - Keltikangas-Jarvinen, Liisa
AU - Kivimaki, Mika
AU - Raitakari, Olli T.
PY - 2011
Y1 - 2011
N2 - Context: Obesity from childhood to adulthood is associated with adverse health later in life. Increased youth BMI is a risk factor for later obesity, but it is unknown whether identification of other risk factors, including recently discovered genetic markers, would help to identify children at risk of developing adult obesity. Objectives: Our objective was to examine the childhood environmental and genetic predictors of adult obesity. Design, Setting, and Participants: We followed 2119 individuals of the Cardiovascular Risk in Young Finns Study for up to 27 yr since baseline (1980, age 3-18 yr). Main Outcome Measure: We evaluated adult obesity [body mass index (BMI) ≥30 kg/m 2]. Results: The independent predictors (P < 0.05) of adult obesity included childhood BMI, C-reactive protein (CRP), family income (inverse), mother's BMI, and polymorphisms near genes TFAP2B, LRRN6C, and FLJ35579. A risk assessment based on childhood BMI, mother's BMI, and family income was superior in predicting obesity compared with the approach using data only on BMI (C-statistics 0.751 vs. 0.772, P=0.0015). Inclusion of data on childhood CRP and novel genetic variants for BMI did not incrementally improve C-value (0.779, P=0.16). A nonlaboratory risk score (childhood BMI, mother's BMI, and family income) predicted adult obesity in all age groups between 3-18 yr (P always <0.001). Conclusions: Childhood BMI, CRP, family income (inversely), mother's BMI, and polymorphisms near genes FLJ35779, TFAP2B, and LRRN6C are independently related to adulthood obesity. However, because genetic risk markers and CRP only marginally improve the prediction, our results indicate that children at high risk of adult obesity can be identified using a simple non-laboratory-based risk assessment.
AB - Context: Obesity from childhood to adulthood is associated with adverse health later in life. Increased youth BMI is a risk factor for later obesity, but it is unknown whether identification of other risk factors, including recently discovered genetic markers, would help to identify children at risk of developing adult obesity. Objectives: Our objective was to examine the childhood environmental and genetic predictors of adult obesity. Design, Setting, and Participants: We followed 2119 individuals of the Cardiovascular Risk in Young Finns Study for up to 27 yr since baseline (1980, age 3-18 yr). Main Outcome Measure: We evaluated adult obesity [body mass index (BMI) ≥30 kg/m 2]. Results: The independent predictors (P < 0.05) of adult obesity included childhood BMI, C-reactive protein (CRP), family income (inverse), mother's BMI, and polymorphisms near genes TFAP2B, LRRN6C, and FLJ35579. A risk assessment based on childhood BMI, mother's BMI, and family income was superior in predicting obesity compared with the approach using data only on BMI (C-statistics 0.751 vs. 0.772, P=0.0015). Inclusion of data on childhood CRP and novel genetic variants for BMI did not incrementally improve C-value (0.779, P=0.16). A nonlaboratory risk score (childhood BMI, mother's BMI, and family income) predicted adult obesity in all age groups between 3-18 yr (P always <0.001). Conclusions: Childhood BMI, CRP, family income (inversely), mother's BMI, and polymorphisms near genes FLJ35779, TFAP2B, and LRRN6C are independently related to adulthood obesity. However, because genetic risk markers and CRP only marginally improve the prediction, our results indicate that children at high risk of adult obesity can be identified using a simple non-laboratory-based risk assessment.
KW - adulthood
KW - childhood
KW - obesity
UR - http://handle.uws.edu.au:8081/1959.7/uws:35840
U2 - 10.1210/jc.2011-1243
DO - 10.1210/jc.2011-1243
M3 - Article
SN - 0021-972X
VL - 96
SP - E1542-E1549
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 9
ER -