TY - JOUR
T1 - Chiral metal-complexes XLII. Reversed-phase high-performance liquid-chromatographic separation of racemic dipeptides as their ternary Co(III) complexes with a chiral triamine
AU - Aldrich-Wright, J. R.
AU - Newman, P. D.
AU - Rao, K. R. N.
AU - Vagg, R. S.
AU - Williams, P. A.
PY - 1995
Y1 - 1995
N2 - The enantiomeric and diastereoisomeric dipeptides Gly-R,S-Val, Gly-R,S-Leu, GIy-R,S-Phe, R,S-Leu-GIy, R,S-Leu-R,S-AIa and R,S-Leu-R,S-Phe have been separated by RP-HPLC methods when coordinated in ternary Co(Ill) complexes [Co(R,R-benzet)(peptidato)] 2+ [benzet = N-benzyl-N'-(2-picolyl-l,2-diaminocyclohexane)], on Amex Prepsil columns under a variety of conditions. A method is illustrated for the recovery of the pure peptides from the separated diastereoisomers. The method appears to be applicable for dipeptides, in general.
AB - The enantiomeric and diastereoisomeric dipeptides Gly-R,S-Val, Gly-R,S-Leu, GIy-R,S-Phe, R,S-Leu-GIy, R,S-Leu-R,S-AIa and R,S-Leu-R,S-Phe have been separated by RP-HPLC methods when coordinated in ternary Co(Ill) complexes [Co(R,R-benzet)(peptidato)] 2+ [benzet = N-benzyl-N'-(2-picolyl-l,2-diaminocyclohexane)], on Amex Prepsil columns under a variety of conditions. A method is illustrated for the recovery of the pure peptides from the separated diastereoisomers. The method appears to be applicable for dipeptides, in general.
UR - http://handle.uws.edu.au:8081/1959.7/532199
U2 - 10.1016/0021-9673(94)01146-6
DO - 10.1016/0021-9673(94)01146-6
M3 - Article
SN - 0021-9673
VL - 693
SP - 366
EP - 370
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - 2
ER -