Chitosan-NVP IPN hydrogels synthesised through photoinitiator-free photopolymerisation technique for drug delivery

Loo-Teck Ng; Salesh N. Swami

Chitosan-NVP IPN hydrogels synthesised through photoinitiator-free photopolymerisation technique for drug delivery

Loo-Teck Ng, Salesh N. Swami

Research output: Chapter in Book / Conference Paper › Conference Paper

Abstract

Interpenetrating polymer network (IPN) hydrogels of chitosan with N-vinylpyrrolidinone (NVP) as well as its copolymer with 2 -hydroxyethyl met hacrylate (HEMA) were synthesised through the photoinitiator - free photopolymerisation technique. These hydrogels exhibited high swelling abilities and fast drug release rates. These tests also revealed that water diffusion into the hydrogels and drug release kinetics, with the exception of the ones with HEMA incorporated did not adhere to the Fickian model. Toxicity tests on human keratinocyte showed no evidence of these gels being toxic.

Original language	English
Title of host publication	Proceedings of the 31st Annual Meeting and Exposition of the Controlled-Release Society, held in Honolulu, Hawaii, USA, 12-16 June, 2004
Publisher	Controlled Release Society
Number of pages	2
Publication status	Published - 2004
Event	Controlled Release Society. Meeting - Duration: 1 Jan 2004 → …

Conference

Conference	Controlled Release Society. Meeting
Period	1/01/04 → …

Keywords

chitosan
polymer networks
colloids
toxicity tests
polymers in medicine

Cite this

@inproceedings{6566c1dec19f4952bbbc589b3fbdf6c2,

title = "Chitosan-NVP IPN hydrogels synthesised through photoinitiator-free photopolymerisation technique for drug delivery",

abstract = "Interpenetrating polymer network (IPN) hydrogels of chitosan with N-vinylpyrrolidinone (NVP) as well as its copolymer with 2 -hydroxyethyl met hacrylate (HEMA) were synthesised through the photoinitiator - free photopolymerisation technique. These hydrogels exhibited high swelling abilities and fast drug release rates. These tests also revealed that water diffusion into the hydrogels and drug release kinetics, with the exception of the ones with HEMA incorporated did not adhere to the Fickian model. Toxicity tests on human keratinocyte showed no evidence of these gels being toxic.",

keywords = "chitosan, polymer networks, colloids, toxicity tests, polymers in medicine",

author = "Loo-Teck Ng and Swami, {Salesh N.}",

year = "2004",

language = "English",

booktitle = "Proceedings of the 31st Annual Meeting and Exposition of the Controlled-Release Society, held in Honolulu, Hawaii, USA, 12-16 June, 2004",

publisher = "Controlled Release Society",

note = "Controlled Release Society. Meeting ; Conference date: 01-01-2004",

}

Chitosan-NVP IPN hydrogels synthesised through photoinitiator-free photopolymerisation technique for drug delivery. / Ng, Loo-Teck; Swami, Salesh N.
Proceedings of the 31st Annual Meeting and Exposition of the Controlled-Release Society, held in Honolulu, Hawaii, USA, 12-16 June, 2004. Controlled Release Society, 2004.

Research output: Chapter in Book / Conference Paper › Conference Paper

TY - GEN

T1 - Chitosan-NVP IPN hydrogels synthesised through photoinitiator-free photopolymerisation technique for drug delivery

AU - Ng, Loo-Teck

AU - Swami, Salesh N.

PY - 2004

Y1 - 2004

N2 - Interpenetrating polymer network (IPN) hydrogels of chitosan with N-vinylpyrrolidinone (NVP) as well as its copolymer with 2 -hydroxyethyl met hacrylate (HEMA) were synthesised through the photoinitiator - free photopolymerisation technique. These hydrogels exhibited high swelling abilities and fast drug release rates. These tests also revealed that water diffusion into the hydrogels and drug release kinetics, with the exception of the ones with HEMA incorporated did not adhere to the Fickian model. Toxicity tests on human keratinocyte showed no evidence of these gels being toxic.

AB - Interpenetrating polymer network (IPN) hydrogels of chitosan with N-vinylpyrrolidinone (NVP) as well as its copolymer with 2 -hydroxyethyl met hacrylate (HEMA) were synthesised through the photoinitiator - free photopolymerisation technique. These hydrogels exhibited high swelling abilities and fast drug release rates. These tests also revealed that water diffusion into the hydrogels and drug release kinetics, with the exception of the ones with HEMA incorporated did not adhere to the Fickian model. Toxicity tests on human keratinocyte showed no evidence of these gels being toxic.

KW - chitosan

KW - polymer networks

KW - colloids

KW - toxicity tests

KW - polymers in medicine

UR - http://handle.uws.edu.au:8081/1959.7/44751

M3 - Conference Paper

BT - Proceedings of the 31st Annual Meeting and Exposition of the Controlled-Release Society, held in Honolulu, Hawaii, USA, 12-16 June, 2004

PB - Controlled Release Society

T2 - Controlled Release Society. Meeting

Y2 - 1 January 2004

ER -

Chitosan-NVP IPN hydrogels synthesised through photoinitiator-free photopolymerisation technique for drug delivery

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Conference

Keywords

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