Circulating microRNA implicated in the TGF-Î² signalling pathway are altered in Marfan Syndrome

Elizabeth N. Robertson; Yaxin Lu; Alex Sahagian; Donna Lai; Murat Kekic; Brett Hambly; Richmond Jeremy

doi:10.1161/circ.132.suppl_3.18889

Circulating microRNA implicated in the TGF-Î² signalling pathway are altered in Marfan Syndrome

Elizabeth N. Robertson, Yaxin Lu, Alex Sahagian, Donna Lai, Murat Kekic, Brett Hambly, Richmond Jeremy

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Thoracic aortic aneurysms in Marfan Syndrome (MFS) caused by mutations in FBN1 are associated with altered TGF-Î² signaling. Regulation of gene expression can occur at the level of microRNA, which can modify signaling pathways. We hypothesized that there would be altered microRNA expression in MFS that may alter the expression of signaling proteins.

Original language	English
Pages (from-to)	A18889-A18889
Number of pages	1
Journal	Circulation
Volume	132
Issue number	Suppl. 3
DOIs	https://doi.org/10.1161/circ.132.suppl_3.18889
Publication status	Published - 2015

Keywords

Marfan Syndrome
thoracic arteries
aneurysms

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10.1161/circ.132.suppl_3.18889

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title = "Circulating microRNA implicated in the TGF-{\^I}² signalling pathway are altered in Marfan Syndrome",

abstract = "Thoracic aortic aneurysms in Marfan Syndrome (MFS) caused by mutations in FBN1 are associated with altered TGF-{\^I}² signaling. Regulation of gene expression can occur at the level of microRNA, which can modify signaling pathways. We hypothesized that there would be altered microRNA expression in MFS that may alter the expression of signaling proteins.",

keywords = "Marfan Syndrome, thoracic arteries, aneurysms",

author = "Robertson, {Elizabeth N.} and Yaxin Lu and Alex Sahagian and Donna Lai and Murat Kekic and Brett Hambly and Richmond Jeremy",

year = "2015",

doi = "10.1161/circ.132.suppl_3.18889",

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T1 - Circulating microRNA implicated in the TGF-Î² signalling pathway are altered in Marfan Syndrome

AU - Robertson, Elizabeth N.

AU - Lu, Yaxin

AU - Sahagian, Alex

AU - Lai, Donna

AU - Kekic, Murat

AU - Hambly, Brett

AU - Jeremy, Richmond

PY - 2015

Y1 - 2015

N2 - Thoracic aortic aneurysms in Marfan Syndrome (MFS) caused by mutations in FBN1 are associated with altered TGF-Î² signaling. Regulation of gene expression can occur at the level of microRNA, which can modify signaling pathways. We hypothesized that there would be altered microRNA expression in MFS that may alter the expression of signaling proteins.

AB - Thoracic aortic aneurysms in Marfan Syndrome (MFS) caused by mutations in FBN1 are associated with altered TGF-Î² signaling. Regulation of gene expression can occur at the level of microRNA, which can modify signaling pathways. We hypothesized that there would be altered microRNA expression in MFS that may alter the expression of signaling proteins.

KW - Marfan Syndrome

KW - thoracic arteries

KW - aneurysms

UR - https://hdl.handle.net/1959.7/uws:58258

U2 - 10.1161/circ.132.suppl_3.18889

DO - 10.1161/circ.132.suppl_3.18889

M3 - Article

SN - 0009-7322

VL - 132

SP - A18889-A18889

JO - Circulation

JF - Circulation

IS - Suppl. 3

ER -

Circulating microRNA implicated in the TGF-Î² signalling pathway are altered in Marfan Syndrome

Abstract

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