Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research

Tony C. Y. Pang; Zhihong Xu; Srinivasa Pothula; Therese Becker; David Goldstein; Romano C. Pirola; Jeremy S. Wilson; Minoti V. Apte

doi:10.1093/carcin/bgx030

Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research

Tony C. Y. Pang, Zhihong Xu, Srinivasa Pothula, Therese Becker, David Goldstein, Romano C. Pirola, Jeremy S. Wilson, Minoti V. Apte

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Pancreatic stellate cells (PSCs) are known to play an important role in facilitating pancreatic cancer progression-both in terms of local tumour growth as well as the establishment of metastases. We have previously demonstrated that PSCs from the primary cancer seed to distant metastatic sites. We therefore hypothesise that PSCs circulate along with pancreatic cancer cells (circulating tumour cells-CTCs) to help create a growth permissive microenvironment at distant metastatic sites. This review aims to explore the concept of circulating PSCs in pancreatic cancer and suggests future directions for research in this area.

Original language	English
Pages (from-to)	588-591
Number of pages	4
Journal	Carcinogenesis
Volume	38
Issue number	6
DOIs	https://doi.org/10.1093/carcin/bgx030
Publication status	Published - 2017

Keywords

cancer
fertility
pancreas
seeds
tumors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/carcin/bgx030

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title = "Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research",

abstract = "Pancreatic stellate cells (PSCs) are known to play an important role in facilitating pancreatic cancer progression-both in terms of local tumour growth as well as the establishment of metastases. We have previously demonstrated that PSCs from the primary cancer seed to distant metastatic sites. We therefore hypothesise that PSCs circulate along with pancreatic cancer cells (circulating tumour cells-CTCs) to help create a growth permissive microenvironment at distant metastatic sites. This review aims to explore the concept of circulating PSCs in pancreatic cancer and suggests future directions for research in this area.",

keywords = "cancer, fertility, pancreas, seeds, tumors",

author = "Pang, {Tony C. Y.} and Zhihong Xu and Srinivasa Pothula and Therese Becker and David Goldstein and Pirola, {Romano C.} and Wilson, {Jeremy S.} and Apte, {Minoti V.}",

year = "2017",

doi = "10.1093/carcin/bgx030",

language = "English",

volume = "38",

pages = "588--591",

journal = "Carcinogenesis",

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T1 - Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research

AU - Pang, Tony C. Y.

AU - Xu, Zhihong

AU - Pothula, Srinivasa

AU - Becker, Therese

AU - Goldstein, David

AU - Pirola, Romano C.

AU - Wilson, Jeremy S.

AU - Apte, Minoti V.

PY - 2017

Y1 - 2017

N2 - Pancreatic stellate cells (PSCs) are known to play an important role in facilitating pancreatic cancer progression-both in terms of local tumour growth as well as the establishment of metastases. We have previously demonstrated that PSCs from the primary cancer seed to distant metastatic sites. We therefore hypothesise that PSCs circulate along with pancreatic cancer cells (circulating tumour cells-CTCs) to help create a growth permissive microenvironment at distant metastatic sites. This review aims to explore the concept of circulating PSCs in pancreatic cancer and suggests future directions for research in this area.

AB - Pancreatic stellate cells (PSCs) are known to play an important role in facilitating pancreatic cancer progression-both in terms of local tumour growth as well as the establishment of metastases. We have previously demonstrated that PSCs from the primary cancer seed to distant metastatic sites. We therefore hypothesise that PSCs circulate along with pancreatic cancer cells (circulating tumour cells-CTCs) to help create a growth permissive microenvironment at distant metastatic sites. This review aims to explore the concept of circulating PSCs in pancreatic cancer and suggests future directions for research in this area.

KW - cancer

KW - fertility

KW - pancreas

KW - seeds

KW - tumors

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:42110

U2 - 10.1093/carcin/bgx030

DO - 10.1093/carcin/bgx030

M3 - Article

SN - 0143-3334

VL - 38

SP - 588

EP - 591

JO - Carcinogenesis

JF - Carcinogenesis

IS - 6

ER -

Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research

Abstract

Keywords

UN SDGs

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