Abstract
Background: Secreted frizzled-related protein 5 (Sfrp5) has been described as a novel anti-inflammatory adipokine similar to adiponectin. In animal models, Sfrp5 deficiency is associated with impaired metabolic phenotype, and cardiovascular abnormalities. However, in humans, data regarding circulating levels of Sfrp5 in diabetes and cardiovascular diseases are limited. In this study, we aimed to investigate whether diabetic status and degree of diabetic control are associated with low Sfrp5 levels in a population with a wide range of body weight. Conclusion: Presence of diabetes as well as poor diabetic control, as assessed by HbA1c, are associated with lower Sfrp5 levels, independent of BMI and other cardiovascular risk factors. Our data support potential pathogenic role of Sfrp5 in diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | S115-S115 |
| Number of pages | 1 |
| Journal | Heart , Lung and Circulation |
| Volume | 26 |
| Issue number | Supplement 2 |
| DOIs | |
| Publication status | Published - 2017 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- diabetes
- diabetics
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