Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer

S. H. Lim; T. M. Becker; W. Chua; N. J. Caixeiro; W. L. Ng; N. Kienzle; A. Tognela; S. Lumba; J. E. J. Rasko; P. de Souza; K. J. Spring

doi:10.1016/j.canlet.2013.12.019

Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer

S. H. Lim
, T. M. Becker
, W. Chua
, N. J. Caixeiro
, W. L. Ng
, N. Kienzle
, A. Tognela
, S. Lumba
, J. E. J. Rasko
, P. de Souza
, K. J. Spring

School of Medicine

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

The detection of circulating tumour cells or circulating free tumour nucleic acids can potentially guide treatment and inform prognosis in colorectal cancer using minimally invasive "liquid biopsies". Current literature supports the notion that high circulating tumour cell counts or presence of tumour nucleic acid correlate with inferior clinical outcomes for patients, but they are not yet part of routine clinical care. Future research evolves around the examination of the molecular phenotype of circulating tumour cells. The key unanswered areas include differentiating between circulating tumour cell presence and their proliferative capacity and dormancy, identifying tumour heterogeneity and understanding the epithelial-mesenchymal transition.

Original language	English
Pages (from-to)	24-33
Number of pages	10
Journal	Cancer Letters
Volume	346
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2013.12.019
Publication status	Published - 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA
circulating tumour cells
colorectal cancer
personalised cancer therapy
predictive biomarkers

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10.1016/j.canlet.2013.12.019

http://ezproxy.uws.edu.au/login?url=http://doi.org/10.1016/j.canlet.2013.12.019

Cite this

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title = "Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer",

abstract = "The detection of circulating tumour cells or circulating free tumour nucleic acids can potentially guide treatment and inform prognosis in colorectal cancer using minimally invasive {"}liquid biopsies{"}. Current literature supports the notion that high circulating tumour cell counts or presence of tumour nucleic acid correlate with inferior clinical outcomes for patients, but they are not yet part of routine clinical care. Future research evolves around the examination of the molecular phenotype of circulating tumour cells. The key unanswered areas include differentiating between circulating tumour cell presence and their proliferative capacity and dormancy, identifying tumour heterogeneity and understanding the epithelial-mesenchymal transition.",

keywords = "DNA, circulating tumour cells, colorectal cancer, personalised cancer therapy, predictive biomarkers",

author = "Lim, \{S. H.\} and Becker, \{T. M.\} and W. Chua and Caixeiro, \{N. J.\} and Ng, \{W. L.\} and N. Kienzle and A. Tognela and S. Lumba and Rasko, \{J. E. J.\} and Souza, \{P. de\} and Spring, \{K. J.\}",

year = "2014",

doi = "10.1016/j.canlet.2013.12.019",

language = "English",

volume = "346",

pages = "24--33",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer

AU - Lim, S. H.

AU - Becker, T. M.

AU - Chua, W.

AU - Caixeiro, N. J.

AU - Ng, W. L.

AU - Kienzle, N.

AU - Tognela, A.

AU - Lumba, S.

AU - Rasko, J. E. J.

AU - Souza, P. de

AU - Spring, K. J.

PY - 2014

Y1 - 2014

N2 - The detection of circulating tumour cells or circulating free tumour nucleic acids can potentially guide treatment and inform prognosis in colorectal cancer using minimally invasive "liquid biopsies". Current literature supports the notion that high circulating tumour cell counts or presence of tumour nucleic acid correlate with inferior clinical outcomes for patients, but they are not yet part of routine clinical care. Future research evolves around the examination of the molecular phenotype of circulating tumour cells. The key unanswered areas include differentiating between circulating tumour cell presence and their proliferative capacity and dormancy, identifying tumour heterogeneity and understanding the epithelial-mesenchymal transition.

AB - The detection of circulating tumour cells or circulating free tumour nucleic acids can potentially guide treatment and inform prognosis in colorectal cancer using minimally invasive "liquid biopsies". Current literature supports the notion that high circulating tumour cell counts or presence of tumour nucleic acid correlate with inferior clinical outcomes for patients, but they are not yet part of routine clinical care. Future research evolves around the examination of the molecular phenotype of circulating tumour cells. The key unanswered areas include differentiating between circulating tumour cell presence and their proliferative capacity and dormancy, identifying tumour heterogeneity and understanding the epithelial-mesenchymal transition.

KW - DNA

KW - circulating tumour cells

KW - colorectal cancer

KW - personalised cancer therapy

KW - predictive biomarkers

UR - http://hdl.handle.net/1959.7/uws:29645

U2 - 10.1016/j.canlet.2013.12.019

DO - 10.1016/j.canlet.2013.12.019

M3 - Article

C2 - 24368189

SN - 0304-3835

VL - 346

SP - 24

EP - 33

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer

Abstract

UN SDGs

Keywords

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