Circulating tumour cells in pancreatic cancer : a systematic review and meta-analysis of clinicopathological implications

Tony C. Y. Pang; Joseph W. Po; Therese M. Becker; David Goldstein; Romano C. Pirola; Jeremy S. Wilson; Minoti V. Apte

doi:10.1016/j.pan.2020.11.022

Circulating tumour cells in pancreatic cancer : a systematic review and meta-analysis of clinicopathological implications

Tony C. Y. Pang, Joseph W. Po, Therese M. Becker, David Goldstein, Romano C. Pirola, Jeremy S. Wilson, Minoti V. Apte

Western Sydney University

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Background: The detection and quantification of circulating tumour cells (CTCs) in pancreatic cancer (PC) has the potential to provide prognostic information. The aim of this review was to provide an overview of the literature surrounding CTCs in PC. Methods: A systematic literature review on CTCs in PC between 2005-2020 was performed. Data based on peripheral vein samples were used to determine the positivity rate of CTCs, their prognostic significance and their relative numbers compared to portal vein (PV) samples. Results: The overall CTC detection rate in forty-four articles was 65% (95%CI: 55-75%). Detection rate for CellSearch was 26% (95%CI: 14-38%), which was lower than for both filtration and microfluidic techniques. In nine studies with >50 patients, overall survival was worse with CTC positivity (HR 1.82; 95%CI: 1.61-2.05). Five of seven studies which described PV CTC collection provided patient-level data. PV CTC yield was 7.7-fold (95%CI 1.35-43.9) that of peripheral blood. Conclusions: CTCs were detected in the peripheral circulation of most patients with PC and may be related to prognosis and disease stage. PV blood contains more CTCs than peripheral blood sampling. This review points to the maturation of techniques of CTC enrichment, and its evidence base for eventual clinical deployment.

Original language	English
Pages (from-to)	103-114
Number of pages	12
Journal	Pancreatology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.pan.2020.11.022
Publication status	Published - 2021

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10.1016/j.pan.2020.11.022

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@article{2106c202547b470cb093d6a6ee330e4b,

title = "Circulating tumour cells in pancreatic cancer : a systematic review and meta-analysis of clinicopathological implications",

abstract = "Background: The detection and quantification of circulating tumour cells (CTCs) in pancreatic cancer (PC) has the potential to provide prognostic information. The aim of this review was to provide an overview of the literature surrounding CTCs in PC. Methods: A systematic literature review on CTCs in PC between 2005-2020 was performed. Data based on peripheral vein samples were used to determine the positivity rate of CTCs, their prognostic significance and their relative numbers compared to portal vein (PV) samples. Results: The overall CTC detection rate in forty-four articles was 65% (95%CI: 55-75%). Detection rate for CellSearch was 26% (95%CI: 14-38%), which was lower than for both filtration and microfluidic techniques. In nine studies with >50 patients, overall survival was worse with CTC positivity (HR 1.82; 95%CI: 1.61-2.05). Five of seven studies which described PV CTC collection provided patient-level data. PV CTC yield was 7.7-fold (95%CI 1.35-43.9) that of peripheral blood. Conclusions: CTCs were detected in the peripheral circulation of most patients with PC and may be related to prognosis and disease stage. PV blood contains more CTCs than peripheral blood sampling. This review points to the maturation of techniques of CTC enrichment, and its evidence base for eventual clinical deployment.",

author = "Pang, {Tony C. Y.} and Po, {Joseph W.} and Becker, {Therese M.} and David Goldstein and Pirola, {Romano C.} and Wilson, {Jeremy S.} and Apte, {Minoti V.}",

year = "2021",

doi = "10.1016/j.pan.2020.11.022",

language = "English",

volume = "21",

pages = "103--114",

journal = "Pancreatology",

issn = "1424-3903",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Circulating tumour cells in pancreatic cancer : a systematic review and meta-analysis of clinicopathological implications

AU - Pang, Tony C. Y.

AU - Po, Joseph W.

AU - Becker, Therese M.

AU - Goldstein, David

AU - Pirola, Romano C.

AU - Wilson, Jeremy S.

AU - Apte, Minoti V.

PY - 2021

Y1 - 2021

N2 - Background: The detection and quantification of circulating tumour cells (CTCs) in pancreatic cancer (PC) has the potential to provide prognostic information. The aim of this review was to provide an overview of the literature surrounding CTCs in PC. Methods: A systematic literature review on CTCs in PC between 2005-2020 was performed. Data based on peripheral vein samples were used to determine the positivity rate of CTCs, their prognostic significance and their relative numbers compared to portal vein (PV) samples. Results: The overall CTC detection rate in forty-four articles was 65% (95%CI: 55-75%). Detection rate for CellSearch was 26% (95%CI: 14-38%), which was lower than for both filtration and microfluidic techniques. In nine studies with >50 patients, overall survival was worse with CTC positivity (HR 1.82; 95%CI: 1.61-2.05). Five of seven studies which described PV CTC collection provided patient-level data. PV CTC yield was 7.7-fold (95%CI 1.35-43.9) that of peripheral blood. Conclusions: CTCs were detected in the peripheral circulation of most patients with PC and may be related to prognosis and disease stage. PV blood contains more CTCs than peripheral blood sampling. This review points to the maturation of techniques of CTC enrichment, and its evidence base for eventual clinical deployment.

AB - Background: The detection and quantification of circulating tumour cells (CTCs) in pancreatic cancer (PC) has the potential to provide prognostic information. The aim of this review was to provide an overview of the literature surrounding CTCs in PC. Methods: A systematic literature review on CTCs in PC between 2005-2020 was performed. Data based on peripheral vein samples were used to determine the positivity rate of CTCs, their prognostic significance and their relative numbers compared to portal vein (PV) samples. Results: The overall CTC detection rate in forty-four articles was 65% (95%CI: 55-75%). Detection rate for CellSearch was 26% (95%CI: 14-38%), which was lower than for both filtration and microfluidic techniques. In nine studies with >50 patients, overall survival was worse with CTC positivity (HR 1.82; 95%CI: 1.61-2.05). Five of seven studies which described PV CTC collection provided patient-level data. PV CTC yield was 7.7-fold (95%CI 1.35-43.9) that of peripheral blood. Conclusions: CTCs were detected in the peripheral circulation of most patients with PC and may be related to prognosis and disease stage. PV blood contains more CTCs than peripheral blood sampling. This review points to the maturation of techniques of CTC enrichment, and its evidence base for eventual clinical deployment.

UR - https://hdl.handle.net/1959.7/uws:61690

U2 - 10.1016/j.pan.2020.11.022

DO - 10.1016/j.pan.2020.11.022

M3 - Article

SN - 1424-3903

VL - 21

SP - 103

EP - 114

JO - Pancreatology

JF - Pancreatology

IS - 1

ER -

Circulating tumour cells in pancreatic cancer : a systematic review and meta-analysis of clinicopathological implications

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