Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma : a pilot study

Tia Morosin; Bruce Ashford; Marie Ranson; Ruta Gupta; Jonathan Clark; N. Gopalakrishna Iyer; Kevin Spring

doi:10.18632/oncotarget.9946

Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma : a pilot study

Tia Morosin, Bruce Ashford, Marie Ranson, Ruta Gupta, Jonathan Clark, N. Gopalakrishna Iyer, Kevin Spring

Western Sydney University

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background: Circulating tumour cells (CTCs) are increasingly being used in the surveillance of cancer, allowing for potential early detection and real-time monitoring of disease progression. The presence of CTCs in patients with metastatic cutaneous head and neck squamous cell carcinoma (cHNSCC) has not been evaluated. Results: CTCs were detected in eight of ten patients with regional metastatic cHNSCC (80%; range 1–44 cells/9 mL blood). CTMs were detected in three of ten patients (30%, range 1–4 cells/9 mL blood). Methods: Preoperative blood samples from ten patients with nodal metastases from cutaneous squamous cell carcinomas (cSCC) were analyzed using the IsoFluxTM System for the detection and enumeration of CTCs and circulating tumour microemboli (CTMs). Conclusions: For the first time CTCs have been detected in patients with nodal metastases from cHNSCC. Further work is required to understand their prognostic significance and potential to directly influence clinical practice.

Original language	English
Pages (from-to)	47111-47115
Number of pages	5
Journal	Oncotarget
Volume	7
Issue number	30
DOIs	https://doi.org/10.18632/oncotarget.9946
Publication status	Published - 2016

Keywords

skin
cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/oncotarget.9946

Cite this

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title = "Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma : a pilot study",

abstract = "Background: Circulating tumour cells (CTCs) are increasingly being used in the surveillance of cancer, allowing for potential early detection and real-time monitoring of disease progression. The presence of CTCs in patients with metastatic cutaneous head and neck squamous cell carcinoma (cHNSCC) has not been evaluated. Results: CTCs were detected in eight of ten patients with regional metastatic cHNSCC (80%; range 1–44 cells/9 mL blood). CTMs were detected in three of ten patients (30%, range 1–4 cells/9 mL blood). Methods: Preoperative blood samples from ten patients with nodal metastases from cutaneous squamous cell carcinomas (cSCC) were analyzed using the IsoFluxTM System for the detection and enumeration of CTCs and circulating tumour microemboli (CTMs). Conclusions: For the first time CTCs have been detected in patients with nodal metastases from cHNSCC. Further work is required to understand their prognostic significance and potential to directly influence clinical practice.",

keywords = "skin, cancer",

author = "Tia Morosin and Bruce Ashford and Marie Ranson and Ruta Gupta and Jonathan Clark and {Gopalakrishna Iyer}, N. and Kevin Spring",

year = "2016",

doi = "10.18632/oncotarget.9946",

language = "English",

volume = "7",

pages = "47111--47115",

journal = "Oncotarget",

issn = "1949-2553",

publisher = "Impact Journals ",

number = "30",

}

TY - JOUR

T1 - Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma : a pilot study

AU - Morosin, Tia

AU - Ashford, Bruce

AU - Ranson, Marie

AU - Gupta, Ruta

AU - Clark, Jonathan

AU - Gopalakrishna Iyer, N.

AU - Spring, Kevin

PY - 2016

Y1 - 2016

N2 - Background: Circulating tumour cells (CTCs) are increasingly being used in the surveillance of cancer, allowing for potential early detection and real-time monitoring of disease progression. The presence of CTCs in patients with metastatic cutaneous head and neck squamous cell carcinoma (cHNSCC) has not been evaluated. Results: CTCs were detected in eight of ten patients with regional metastatic cHNSCC (80%; range 1–44 cells/9 mL blood). CTMs were detected in three of ten patients (30%, range 1–4 cells/9 mL blood). Methods: Preoperative blood samples from ten patients with nodal metastases from cutaneous squamous cell carcinomas (cSCC) were analyzed using the IsoFluxTM System for the detection and enumeration of CTCs and circulating tumour microemboli (CTMs). Conclusions: For the first time CTCs have been detected in patients with nodal metastases from cHNSCC. Further work is required to understand their prognostic significance and potential to directly influence clinical practice.

AB - Background: Circulating tumour cells (CTCs) are increasingly being used in the surveillance of cancer, allowing for potential early detection and real-time monitoring of disease progression. The presence of CTCs in patients with metastatic cutaneous head and neck squamous cell carcinoma (cHNSCC) has not been evaluated. Results: CTCs were detected in eight of ten patients with regional metastatic cHNSCC (80%; range 1–44 cells/9 mL blood). CTMs were detected in three of ten patients (30%, range 1–4 cells/9 mL blood). Methods: Preoperative blood samples from ten patients with nodal metastases from cutaneous squamous cell carcinomas (cSCC) were analyzed using the IsoFluxTM System for the detection and enumeration of CTCs and circulating tumour microemboli (CTMs). Conclusions: For the first time CTCs have been detected in patients with nodal metastases from cHNSCC. Further work is required to understand their prognostic significance and potential to directly influence clinical practice.

KW - skin

KW - cancer

UR - http://handle.uws.edu.au:8081/1959.7/uws:35905

U2 - 10.18632/oncotarget.9946

DO - 10.18632/oncotarget.9946

M3 - Article

SN - 1949-2553

VL - 7

SP - 47111

EP - 47115

JO - Oncotarget

JF - Oncotarget

IS - 30

ER -

Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma : a pilot study

Abstract

Keywords

UN SDGs

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