Clarion call for histopathological clot analysis in "cryptogenic" ischemic stroke : implications for diagnosis and treatment

Sonu Bhaskar; Dennis Cordato; Cecilia Cappelen-Smith; Andrew Cheung; David Ledingham; David Celermajer; Christopher Levi

doi:10.1002/acn3.500

Clarion call for histopathological clot analysis in "cryptogenic" ischemic stroke : implications for diagnosis and treatment

Sonu Bhaskar, Dennis Cordato, Cecilia Cappelen-Smith, Andrew Cheung, David Ledingham, David Celermajer, Christopher Levi

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Diagnosis, treatment, and secondary management of cryptogenic stroke patients pose a formidable challenge. The scenario is further complicated in patients with native and prosthetic valvular heart disease. We present a case study of a 36-year-old man who received intravenous thrombolysis (IV-tPA) and endovascular thrombectomy (EVT) for presumed "cryptogenic" complete middle cerebral artery infarction who made a surprisingly excellent clinical recovery despite poor baseline and postintervention neuroimaging. Retrospective gram stain of his clot confirmed a diagnosis of infective endocarditis. This raises an important issue regarding need for more routine histopathological analysis of clot retrieved after EVT in "cryptogenic" stroke patients particularly those with valvular heart disease.

Original language	English
Pages (from-to)	926-930
Number of pages	5
Journal	Annals of Clinical and Translational Neurology
Volume	4
Issue number	12
DOIs	https://doi.org/10.1002/acn3.500
Publication status	Published - 2017

Open Access - Access Right Statement

©2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use ad distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made

Keywords

diagnosis
management
stroke
treatment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/acn3.500

Cite this

@article{758ec9f1f5a64546953ead94545ac5b4,

title = "Clarion call for histopathological clot analysis in {"}cryptogenic{"} ischemic stroke : implications for diagnosis and treatment",

abstract = "Diagnosis, treatment, and secondary management of cryptogenic stroke patients pose a formidable challenge. The scenario is further complicated in patients with native and prosthetic valvular heart disease. We present a case study of a 36-year-old man who received intravenous thrombolysis (IV-tPA) and endovascular thrombectomy (EVT) for presumed {"}cryptogenic{"} complete middle cerebral artery infarction who made a surprisingly excellent clinical recovery despite poor baseline and postintervention neuroimaging. Retrospective gram stain of his clot confirmed a diagnosis of infective endocarditis. This raises an important issue regarding need for more routine histopathological analysis of clot retrieved after EVT in {"}cryptogenic{"} stroke patients particularly those with valvular heart disease.",

keywords = "diagnosis, management, stroke, treatment",

author = "Sonu Bhaskar and Dennis Cordato and Cecilia Cappelen-Smith and Andrew Cheung and David Ledingham and David Celermajer and Christopher Levi",

year = "2017",

doi = "10.1002/acn3.500",

language = "English",

volume = "4",

pages = "926--930",

journal = "Annals of Clinical and Translational Neurology",

issn = "2328-9503",

publisher = "John Wiley & Sons",

number = "12",

}

TY - JOUR

T1 - Clarion call for histopathological clot analysis in "cryptogenic" ischemic stroke : implications for diagnosis and treatment

AU - Bhaskar, Sonu

AU - Cordato, Dennis

AU - Cappelen-Smith, Cecilia

AU - Cheung, Andrew

AU - Ledingham, David

AU - Celermajer, David

AU - Levi, Christopher

PY - 2017

Y1 - 2017

N2 - Diagnosis, treatment, and secondary management of cryptogenic stroke patients pose a formidable challenge. The scenario is further complicated in patients with native and prosthetic valvular heart disease. We present a case study of a 36-year-old man who received intravenous thrombolysis (IV-tPA) and endovascular thrombectomy (EVT) for presumed "cryptogenic" complete middle cerebral artery infarction who made a surprisingly excellent clinical recovery despite poor baseline and postintervention neuroimaging. Retrospective gram stain of his clot confirmed a diagnosis of infective endocarditis. This raises an important issue regarding need for more routine histopathological analysis of clot retrieved after EVT in "cryptogenic" stroke patients particularly those with valvular heart disease.

AB - Diagnosis, treatment, and secondary management of cryptogenic stroke patients pose a formidable challenge. The scenario is further complicated in patients with native and prosthetic valvular heart disease. We present a case study of a 36-year-old man who received intravenous thrombolysis (IV-tPA) and endovascular thrombectomy (EVT) for presumed "cryptogenic" complete middle cerebral artery infarction who made a surprisingly excellent clinical recovery despite poor baseline and postintervention neuroimaging. Retrospective gram stain of his clot confirmed a diagnosis of infective endocarditis. This raises an important issue regarding need for more routine histopathological analysis of clot retrieved after EVT in "cryptogenic" stroke patients particularly those with valvular heart disease.

KW - diagnosis

KW - management

KW - stroke

KW - treatment

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:45368

U2 - 10.1002/acn3.500

DO - 10.1002/acn3.500

M3 - Article

SN - 2328-9503

VL - 4

SP - 926

EP - 930

JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

IS - 12

ER -

Clarion call for histopathological clot analysis in "cryptogenic" ischemic stroke : implications for diagnosis and treatment

Abstract

Open Access - Access Right Statement

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this