Closed-loop efficient searching of optimal electrical stimulation parameters for preferential excitation of retinal ganglion cells

Tianruo Guo; Chih Yu Yang; David Tsai; Madhuvanthi Muralidharan; Gregg J. Suaning; John W. Morley; Socrates Dokos; Nigel H. Lovell

doi:10.3389/fnins.2018.00168

Closed-loop efficient searching of optimal electrical stimulation parameters for preferential excitation of retinal ganglion cells

Tianruo Guo, Chih Yu Yang, David Tsai, Madhuvanthi Muralidharan, Gregg J. Suaning, John W. Morley, Socrates Dokos, Nigel H. Lovell

Western Sydney University

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

The ability for visual prostheses to preferentially activate functionally-distinct retinal ganglion cells (RGCs) is important for improving visual perception. This study investigates the use of high frequency stimulation (HFS) to elicit RGC activation, using a closed-loop algorithm to search for optimal stimulation parameters for preferential ON and OFF RGC activation, resembling natural physiological neural encoding in response to visual Stimuli. We evaluated the performance of a wide range of electrical stimulation amplitudes and frequencies on RGC responses in vitro using murine retinal preparations. It was possible to preferentially excite either ON or OFF RGCs by adjusting amplitudes and frequencies in HFS. ON RGCs can be preferentially activated at relatively higher stimulation amplitudes (>150 uA) and frequencies (2-6.25 kHz) while OFF RGCs are activated by lower stimulation amplitudes (40-90 uA) across all tested frequencies (1-6.25 kHz). These stimuli also showed great promise in eliciting RGC responses that parallel natural RGC encoding: ON RGCs exhibited an increase in spiking activity during electrical stimulation while OFF RGCs exhibited decreased spiking activity, given the same stimulation amplitude. In conjunction with the in vitro studies, in silico simulations indicated that optimal HFS parameters could be rapidly identified in practice, whilst sampling spiking activity of relevant neuronal subtypes. This closed-loop approach represents a step forward in modulating stimulation parameters to achieve appropriate neural encoding in retinal prostheses, advancing control over RGC subtypes activated by electrical stimulation.

Original language	English
Article number	168
Number of pages	12
Journal	Frontiers in Neuroscience
Volume	12
DOIs	https://doi.org/10.3389/fnins.2018.00168
Publication status	Published - 2018

Open Access - Access Right Statement

© 2018 Guo, Yang, Tsai, Muralidharan, Suaning, Morley, Dokos and Lovell. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Keywords

artificial vision
prosthesis
retinal ganglion cells

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10.3389/fnins.2018.00168

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title = "Closed-loop efficient searching of optimal electrical stimulation parameters for preferential excitation of retinal ganglion cells",

abstract = "The ability for visual prostheses to preferentially activate functionally-distinct retinal ganglion cells (RGCs) is important for improving visual perception. This study investigates the use of high frequency stimulation (HFS) to elicit RGC activation, using a closed-loop algorithm to search for optimal stimulation parameters for preferential ON and OFF RGC activation, resembling natural physiological neural encoding in response to visual Stimuli. We evaluated the performance of a wide range of electrical stimulation amplitudes and frequencies on RGC responses in vitro using murine retinal preparations. It was possible to preferentially excite either ON or OFF RGCs by adjusting amplitudes and frequencies in HFS. ON RGCs can be preferentially activated at relatively higher stimulation amplitudes (>150 uA) and frequencies (2-6.25 kHz) while OFF RGCs are activated by lower stimulation amplitudes (40-90 uA) across all tested frequencies (1-6.25 kHz). These stimuli also showed great promise in eliciting RGC responses that parallel natural RGC encoding: ON RGCs exhibited an increase in spiking activity during electrical stimulation while OFF RGCs exhibited decreased spiking activity, given the same stimulation amplitude. In conjunction with the in vitro studies, in silico simulations indicated that optimal HFS parameters could be rapidly identified in practice, whilst sampling spiking activity of relevant neuronal subtypes. This closed-loop approach represents a step forward in modulating stimulation parameters to achieve appropriate neural encoding in retinal prostheses, advancing control over RGC subtypes activated by electrical stimulation.",

keywords = "artificial vision, prosthesis, retinal ganglion cells",

author = "Tianruo Guo and Yang, {Chih Yu} and David Tsai and Madhuvanthi Muralidharan and Suaning, {Gregg J.} and Morley, {John W.} and Socrates Dokos and Lovell, {Nigel H.}",

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AU - Guo, Tianruo

AU - Yang, Chih Yu

AU - Tsai, David

AU - Muralidharan, Madhuvanthi

AU - Suaning, Gregg J.

AU - Morley, John W.

AU - Dokos, Socrates

AU - Lovell, Nigel H.

PY - 2018

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AB - The ability for visual prostheses to preferentially activate functionally-distinct retinal ganglion cells (RGCs) is important for improving visual perception. This study investigates the use of high frequency stimulation (HFS) to elicit RGC activation, using a closed-loop algorithm to search for optimal stimulation parameters for preferential ON and OFF RGC activation, resembling natural physiological neural encoding in response to visual Stimuli. We evaluated the performance of a wide range of electrical stimulation amplitudes and frequencies on RGC responses in vitro using murine retinal preparations. It was possible to preferentially excite either ON or OFF RGCs by adjusting amplitudes and frequencies in HFS. ON RGCs can be preferentially activated at relatively higher stimulation amplitudes (>150 uA) and frequencies (2-6.25 kHz) while OFF RGCs are activated by lower stimulation amplitudes (40-90 uA) across all tested frequencies (1-6.25 kHz). These stimuli also showed great promise in eliciting RGC responses that parallel natural RGC encoding: ON RGCs exhibited an increase in spiking activity during electrical stimulation while OFF RGCs exhibited decreased spiking activity, given the same stimulation amplitude. In conjunction with the in vitro studies, in silico simulations indicated that optimal HFS parameters could be rapidly identified in practice, whilst sampling spiking activity of relevant neuronal subtypes. This closed-loop approach represents a step forward in modulating stimulation parameters to achieve appropriate neural encoding in retinal prostheses, advancing control over RGC subtypes activated by electrical stimulation.

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KW - prosthesis

KW - retinal ganglion cells

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:46308

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DO - 10.3389/fnins.2018.00168

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JO - Frontiers in Neuroscience

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M1 - 168

ER -

Closed-loop efficient searching of optimal electrical stimulation parameters for preferential excitation of retinal ganglion cells

Abstract

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