Co-delivery of gemcitabine and Triapine by calcium carbonate nanoparticles against chemoresistant pancreatic cancer

Yongmei Zhao, Yuanlin Zheng, Yan Zhu, Kai Ding, Mengjiao Zhou, Tianqing Liu

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Pancreatic cancer is a malignant disease with high mortality, and its systemic treatment strategy mainly focuses on chemotherapy. Yet, the overall prognosis of pancreatic cancer patients is still extremely poor with a low survival rate. Gemcitabine (GEM) is a widely used chemotherapeutic agent for the treatment of pancreatic cancer. However, GEM chemoresistance remains the major challenge. In this study, we prepared calcium carbonate nanoparticles (CaCO3 NPs) loaded with a nucleotide reductase inhibitor (Triapine) and GEM to suppress the GEM resistance of pancreatic cancer cells (PANC-1/GEM) and solve the problem of poor solubility of Triapine. CaCO3-GEM-Triapine NPs nano-formulations enhanced the therapeutic effect of GEM-based chemotherapy by inhibiting cancer cell proliferation, migration, and resistance to GEM using both 2D PANC-1/GEM cells and 3D tumor spheroids. The study indicated that CaCO3 NPs loaded with GEM and Triapine could provide an effective treatment option to overcome drug resistance in pancreatic cancer.
Original languageEnglish
Article number122844
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume636
DOIs
Publication statusPublished - 5 Apr 2023

Bibliographical note

Publisher Copyright:
© 2023

Open Access - Access Right Statement

© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).

Keywords

  • Calcium carbonate nanoparticles
  • Gemcitabine
  • Pancreatic cancer
  • Triapine
  • Drug resistance

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