Cold case : the disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970's Egypt

Joachim R. de Miranda; Laura E. Brettell; Nor Chejanovsky; Anna K. Childers; Anne Dalmon; Ward Deboutte; Dirk C. de Graaf; Vincent Doublet; Haftom Gebremedhn; Elke Genersch; Sebastian Gisder; Fredrik Granberg; Nizar J. Haddad; Rene Kaden; Robyn Manley; Jelle Matthijnssens; Ivan Meeus; Hussein Migdadi; Meghan O. Milbrath; Fanny Mondet; Emily J. Remnant; John M. K. Roberts; Eugene V. Ryabov; Noa Sela; Guy Smagghe; Hema Somanathan; Lena Wilfert; Owen N. Wright; Stephen J. Martin; Brenda V. Ball

doi:10.1186/s12985-022-01740-2

Cold case : the disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970's Egypt

Joachim R. de Miranda, Laura E. Brettell, Nor Chejanovsky, Anna K. Childers, Anne Dalmon, Ward Deboutte, Dirk C. de Graaf, Vincent Doublet, Haftom Gebremedhn, Elke Genersch, Sebastian Gisder, Fredrik Granberg, Nizar J. Haddad, Rene Kaden, Robyn Manley, Jelle Matthijnssens, Ivan Meeus, Hussein Migdadi, Meghan O. Milbrath, Fanny MondetEmily J. Remnant, John M. K. Roberts, Eugene V. Ryabov, Noa Sela, Guy Smagghe, Hema Somanathan, Lena Wilfert, Owen N. Wright, Stephen J. Martin, Brenda V. Ball

Western Sydney University

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes.

Original language	English
Article number	12
Number of pages	11
Journal	Virology Journal
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12985-022-01740-2
Publication status	Published - 2022

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de Miranda, J. R., Brettell, L. E., Chejanovsky, N., Childers, A. K., Dalmon, A., Deboutte, W., de Graaf, D. C., Doublet, V., Gebremedhn, H., Genersch, E., Gisder, S., Granberg, F., Haddad, N. J., Kaden, R., Manley, R., Matthijnssens, J., Meeus, I., Migdadi, H., Milbrath, M. O., ... Ball, B. V. (2022). Cold case : the disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970's Egypt. Virology Journal, 19(1), Article 12. https://doi.org/10.1186/s12985-022-01740-2

@article{c57678aefe3c4488a0205e480eadbcda,

title = "Cold case : the disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970's Egypt",

abstract = "In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes.",

author = "{de Miranda}, {Joachim R.} and Brettell, {Laura E.} and Nor Chejanovsky and Childers, {Anna K.} and Anne Dalmon and Ward Deboutte and {de Graaf}, {Dirk C.} and Vincent Doublet and Haftom Gebremedhn and Elke Genersch and Sebastian Gisder and Fredrik Granberg and Haddad, {Nizar J.} and Rene Kaden and Robyn Manley and Jelle Matthijnssens and Ivan Meeus and Hussein Migdadi and Milbrath, {Meghan O.} and Fanny Mondet and Remnant, {Emily J.} and Roberts, {John M. K.} and Ryabov, {Eugene V.} and Noa Sela and Guy Smagghe and Hema Somanathan and Lena Wilfert and Wright, {Owen N.} and Martin, {Stephen J.} and Ball, {Brenda V.}",

year = "2022",

doi = "10.1186/s12985-022-01740-2",

language = "English",

volume = "19",

journal = "Virology Journal",

issn = "1743-422X",

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de Miranda, JR, Brettell, LE, Chejanovsky, N, Childers, AK, Dalmon, A, Deboutte, W, de Graaf, DC, Doublet, V, Gebremedhn, H, Genersch, E, Gisder, S, Granberg, F, Haddad, NJ, Kaden, R, Manley, R, Matthijnssens, J, Meeus, I, Migdadi, H, Milbrath, MO, Mondet, F, Remnant, EJ, Roberts, JMK, Ryabov, EV, Sela, N, Smagghe, G, Somanathan, H, Wilfert, L, Wright, ON, Martin, SJ & Ball, BV 2022, 'Cold case : the disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970's Egypt', Virology Journal, vol. 19, no. 1, 12. https://doi.org/10.1186/s12985-022-01740-2

TY - JOUR

T1 - Cold case : the disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970's Egypt

AU - de Miranda, Joachim R.

AU - Brettell, Laura E.

AU - Chejanovsky, Nor

AU - Childers, Anna K.

AU - Dalmon, Anne

AU - Deboutte, Ward

AU - de Graaf, Dirk C.

AU - Doublet, Vincent

AU - Gebremedhn, Haftom

AU - Genersch, Elke

AU - Gisder, Sebastian

AU - Granberg, Fredrik

AU - Haddad, Nizar J.

AU - Kaden, Rene

AU - Manley, Robyn

AU - Matthijnssens, Jelle

AU - Meeus, Ivan

AU - Migdadi, Hussein

AU - Milbrath, Meghan O.

AU - Mondet, Fanny

AU - Remnant, Emily J.

AU - Roberts, John M. K.

AU - Ryabov, Eugene V.

AU - Sela, Noa

AU - Smagghe, Guy

AU - Somanathan, Hema

AU - Wilfert, Lena

AU - Wright, Owen N.

AU - Martin, Stephen J.

AU - Ball, Brenda V.

PY - 2022

Y1 - 2022

N2 - In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes.

AB - In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes.

UR - https://hdl.handle.net/1959.7/uws:76158

U2 - 10.1186/s12985-022-01740-2

DO - 10.1186/s12985-022-01740-2

M3 - Article

SN - 1743-422X

VL - 19

JO - Virology Journal

JF - Virology Journal

IS - 1

M1 - 12

ER -

Cold case : the disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970's Egypt

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