Abstract
This review explores the chief genetic and epigenetic events that promote pathological progression in colorectal carcinogenesis. This article discusses the molecular and pathological basis for classifying colorectal neoplasia into suppressor, mutator and methylator pathways. These differing mechanisms of genomic instability are associated with specific cancer characteristics, and may provide the opportunity for more effective prevention and surveillance strategies in the future. This is the first review in a series of five topics outlining important and developing aspects of colorectal cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 3784-3791 |
| Number of pages | 8 |
| Journal | World Journal of Gastroenterology |
| Volume | 13 |
| Issue number | 28 |
| DOIs | |
| Publication status | Published - 28 Jul 2007 |
| Externally published | Yes |
Keywords
- Adenoma-carcinoma sequence
- Adenomas
- Colorectal cancer
- CpG Island methylator phenotype
- Hyperplastic polyps, Microsatellite instability
- Neoplastic processes
- Serrated adenoma
