Combination of panax ginseng and ginkgo biloba extracts attenuate cerebral ischemia injury with modulation of NLRP3 inflammasome and CAMK4/CREB pathway

Aimei Zhao; Nan Liu; Guozhi Jiang; Li Xu; Mingjiang Yao; Yehao Zhang; Bingjie Xue; Bo Ma; Dennis Chang; Yujing Feng; Yunyao Jiang; Jianxun Liu; Guoping Zhou

doi:10.3389/fphar.2022.980449

Combination of panax ginseng and ginkgo biloba extracts attenuate cerebral ischemia injury with modulation of NLRP3 inflammasome and CAMK4/CREB pathway

Aimei Zhao
, Nan Liu
, Guozhi Jiang
, Li Xu
, Mingjiang Yao
, Yehao Zhang
, Bingjie Xue
, Bo Ma
, Dennis Chang
, Yujing Feng
, Yunyao Jiang
, Jianxun Liu
, Guoping Zhou

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Stroke is a major cause of death and disability throughout the world. A combination of Panax Ginseng and Ginkgo biloba extracts (CGGE) is an effective treatment for nervous system diseases, but the neuroprotective mechanism underlying CGGE remains unclear. Both network analysis and experimental research were employed to explore the potential mechanism of CGGE in treating ischemic stroke (IS). Network analysis identified a total number of 133 potential targets for 34 active ingredients and 239 IS-related targets. What’s more, several processes that might involve the regulation of CGGE against IS were identified, including long-term potentiation, cAMP signaling pathway, neurotrophin signaling pathway, and Nod-like receptor signaling pathway. Our studies in animal models suggested that CGGE could reduce inflammatory response by inhibiting the activity of Nod-like receptor, pyrin containing 3 (NLRP3) inflammasome, and maintain the balance of glutamate (Glu)/gamma-aminobutyric acid (GABA) via activating calmodulin-dependent protein kinase type Ⅳ (CAMK4)/cyclic AMP-responsive element-binding protein (CREB) pathway. These findings indicated the neuroprotective effects of CGGE, possibly improving neuroinflammation and excitotoxicity by regulating the NLRP3 inflammasome and CAMK4/CREB pathway.

Original language	English
Article number	980449
Number of pages	15
Journal	Frontiers in Pharmacology
Volume	13
DOIs	https://doi.org/10.3389/fphar.2022.980449
Publication status	Published - 25 Aug 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Zhao, Liu, Jiang, Xu, Yao, Zhang, Xue, Ma, Chang, Feng, Jiang, Liu and Zhou.

Open Access - Access Right Statement

© 2022 The authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SDG 3 Good Health and Well-being

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10.3389/fphar.2022.980449

Cite this

Zhao, A., Liu, N., Jiang, G., Xu, L., Yao, M., Zhang, Y., Xue, B., Ma, B., Chang, D., Feng, Y., Jiang, Y., Liu, J., & Zhou, G. (2022). Combination of panax ginseng and ginkgo biloba extracts attenuate cerebral ischemia injury with modulation of NLRP3 inflammasome and CAMK4/CREB pathway. Frontiers in Pharmacology, 13, Article 980449. https://doi.org/10.3389/fphar.2022.980449

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title = "Combination of panax ginseng and ginkgo biloba extracts attenuate cerebral ischemia injury with modulation of NLRP3 inflammasome and CAMK4/CREB pathway",

abstract = "Stroke is a major cause of death and disability throughout the world. A combination of Panax Ginseng and Ginkgo biloba extracts (CGGE) is an effective treatment for nervous system diseases, but the neuroprotective mechanism underlying CGGE remains unclear. Both network analysis and experimental research were employed to explore the potential mechanism of CGGE in treating ischemic stroke (IS). Network analysis identified a total number of 133 potential targets for 34 active ingredients and 239 IS-related targets. What{\textquoteright}s more, several processes that might involve the regulation of CGGE against IS were identified, including long-term potentiation, cAMP signaling pathway, neurotrophin signaling pathway, and Nod-like receptor signaling pathway. Our studies in animal models suggested that CGGE could reduce inflammatory response by inhibiting the activity of Nod-like receptor, pyrin containing 3 (NLRP3) inflammasome, and maintain the balance of glutamate (Glu)/gamma-aminobutyric acid (GABA) via activating calmodulin-dependent protein kinase type Ⅳ (CAMK4)/cyclic AMP-responsive element-binding protein (CREB) pathway. These findings indicated the neuroprotective effects of CGGE, possibly improving neuroinflammation and excitotoxicity by regulating the NLRP3 inflammasome and CAMK4/CREB pathway.",

author = "Aimei Zhao and Nan Liu and Guozhi Jiang and Li Xu and Mingjiang Yao and Yehao Zhang and Bingjie Xue and Bo Ma and Dennis Chang and Yujing Feng and Yunyao Jiang and Jianxun Liu and Guoping Zhou",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Zhao, Liu, Jiang, Xu, Yao, Zhang, Xue, Ma, Chang, Feng, Jiang, Liu and Zhou.",

year = "2022",

month = aug,

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doi = "10.3389/fphar.2022.980449",

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AU - Zhao, Aimei

AU - Liu, Nan

AU - Jiang, Guozhi

AU - Xu, Li

AU - Yao, Mingjiang

AU - Zhang, Yehao

AU - Xue, Bingjie

AU - Ma, Bo

AU - Chang, Dennis

AU - Feng, Yujing

AU - Jiang, Yunyao

AU - Liu, Jianxun

AU - Zhou, Guoping

PY - 2022/8/25

Y1 - 2022/8/25

N2 - Stroke is a major cause of death and disability throughout the world. A combination of Panax Ginseng and Ginkgo biloba extracts (CGGE) is an effective treatment for nervous system diseases, but the neuroprotective mechanism underlying CGGE remains unclear. Both network analysis and experimental research were employed to explore the potential mechanism of CGGE in treating ischemic stroke (IS). Network analysis identified a total number of 133 potential targets for 34 active ingredients and 239 IS-related targets. What’s more, several processes that might involve the regulation of CGGE against IS were identified, including long-term potentiation, cAMP signaling pathway, neurotrophin signaling pathway, and Nod-like receptor signaling pathway. Our studies in animal models suggested that CGGE could reduce inflammatory response by inhibiting the activity of Nod-like receptor, pyrin containing 3 (NLRP3) inflammasome, and maintain the balance of glutamate (Glu)/gamma-aminobutyric acid (GABA) via activating calmodulin-dependent protein kinase type Ⅳ (CAMK4)/cyclic AMP-responsive element-binding protein (CREB) pathway. These findings indicated the neuroprotective effects of CGGE, possibly improving neuroinflammation and excitotoxicity by regulating the NLRP3 inflammasome and CAMK4/CREB pathway.

AB - Stroke is a major cause of death and disability throughout the world. A combination of Panax Ginseng and Ginkgo biloba extracts (CGGE) is an effective treatment for nervous system diseases, but the neuroprotective mechanism underlying CGGE remains unclear. Both network analysis and experimental research were employed to explore the potential mechanism of CGGE in treating ischemic stroke (IS). Network analysis identified a total number of 133 potential targets for 34 active ingredients and 239 IS-related targets. What’s more, several processes that might involve the regulation of CGGE against IS were identified, including long-term potentiation, cAMP signaling pathway, neurotrophin signaling pathway, and Nod-like receptor signaling pathway. Our studies in animal models suggested that CGGE could reduce inflammatory response by inhibiting the activity of Nod-like receptor, pyrin containing 3 (NLRP3) inflammasome, and maintain the balance of glutamate (Glu)/gamma-aminobutyric acid (GABA) via activating calmodulin-dependent protein kinase type Ⅳ (CAMK4)/cyclic AMP-responsive element-binding protein (CREB) pathway. These findings indicated the neuroprotective effects of CGGE, possibly improving neuroinflammation and excitotoxicity by regulating the NLRP3 inflammasome and CAMK4/CREB pathway.

UR - https://hdl.handle.net/1959.7/uws:70423

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DO - 10.3389/fphar.2022.980449

M3 - Article

SN - 1663-9812

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JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

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Combination of panax ginseng and ginkgo biloba extracts attenuate cerebral ischemia injury with modulation of NLRP3 inflammasome and CAMK4/CREB pathway

Abstract

Bibliographical note

Open Access - Access Right Statement

UN SDGs

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