Combining the platinum(II) drug candidate kiteplatin with 1,10-phenanthroline analogues

Benjamin J. Pages; Jennette Sakoff; Jayne Gilbert; Yingjie Zhang; Sharon M. Kelly; James D. Hoeschele; Janice R. Aldrich-Wright

doi:10.1039/c7dt04108j

Combining the platinum(II) drug candidate kiteplatin with 1,10-phenanthroline analogues

Benjamin J. Pages, Jennette Sakoff, Jayne Gilbert, Yingjie Zhang, Sharon M. Kelly, James D. Hoeschele, Janice R. Aldrich-Wright

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Platinum complexes of the type [Pt(PL)(AL)]2+ where PL is a derivative of 1,10-phenanthroline and AL is cis-1,4-diaminocyclohexane (1,4-dach), have been synthesised and characterised by ultraviolet spectroscopy,elemental microanalysis, nuclear magnetic resonance and X-ray crystallography. The calf-thymus DNAbinding affinity of these complexes was determined by isothermal titration calorimetry, revealing higherDNA affinity than their 1S,2S-diaminocyclohexane analogues. In vitro cytotoxicity was assessed in eleven human cell lines, revealing unexpectedly low activity for the 1,4-dach complexes.

Original language	English
Pages (from-to)	2156-2163
Number of pages	8
Journal	Dalton Transactions
Volume	47
Issue number	7
DOIs	https://doi.org/10.1039/c7dt04108j
Publication status	Published - 2018

Keywords

phenanthroline
platinum
spectrum analysis

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10.1039/c7dt04108j

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title = "Combining the platinum(II) drug candidate kiteplatin with 1,10-phenanthroline analogues",

abstract = "Platinum complexes of the type [Pt(PL)(AL)]2+ where PL is a derivative of 1,10-phenanthroline and AL is cis-1,4-diaminocyclohexane (1,4-dach), have been synthesised and characterised by ultraviolet spectroscopy,elemental microanalysis, nuclear magnetic resonance and X-ray crystallography. The calf-thymus DNAbinding affinity of these complexes was determined by isothermal titration calorimetry, revealing higherDNA affinity than their 1S,2S-diaminocyclohexane analogues. In vitro cytotoxicity was assessed in eleven human cell lines, revealing unexpectedly low activity for the 1,4-dach complexes.",

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doi = "10.1039/c7dt04108j",

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T1 - Combining the platinum(II) drug candidate kiteplatin with 1,10-phenanthroline analogues

AU - Pages, Benjamin J.

AU - Sakoff, Jennette

AU - Gilbert, Jayne

AU - Zhang, Yingjie

AU - Kelly, Sharon M.

AU - Hoeschele, James D.

AU - Aldrich-Wright, Janice R.

PY - 2018

Y1 - 2018

N2 - Platinum complexes of the type [Pt(PL)(AL)]2+ where PL is a derivative of 1,10-phenanthroline and AL is cis-1,4-diaminocyclohexane (1,4-dach), have been synthesised and characterised by ultraviolet spectroscopy,elemental microanalysis, nuclear magnetic resonance and X-ray crystallography. The calf-thymus DNAbinding affinity of these complexes was determined by isothermal titration calorimetry, revealing higherDNA affinity than their 1S,2S-diaminocyclohexane analogues. In vitro cytotoxicity was assessed in eleven human cell lines, revealing unexpectedly low activity for the 1,4-dach complexes.

AB - Platinum complexes of the type [Pt(PL)(AL)]2+ where PL is a derivative of 1,10-phenanthroline and AL is cis-1,4-diaminocyclohexane (1,4-dach), have been synthesised and characterised by ultraviolet spectroscopy,elemental microanalysis, nuclear magnetic resonance and X-ray crystallography. The calf-thymus DNAbinding affinity of these complexes was determined by isothermal titration calorimetry, revealing higherDNA affinity than their 1S,2S-diaminocyclohexane analogues. In vitro cytotoxicity was assessed in eleven human cell lines, revealing unexpectedly low activity for the 1,4-dach complexes.

KW - phenanthroline

KW - platinum

KW - spectrum analysis

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:44491

U2 - 10.1039/c7dt04108j

DO - 10.1039/c7dt04108j

M3 - Article

SN - 1477-9226

VL - 47

SP - 2156

EP - 2163

JO - Dalton Transactions

JF - Dalton Transactions

IS - 7

ER -

Combining the platinum(II) drug candidate kiteplatin with 1,10-phenanthroline analogues

Abstract

Keywords

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