TY - JOUR
T1 - Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades
T2 - a multiethnic prospective cohort in New Zealand
AU - Yu, Dahai
AU - Fu, Hang
AU - Zhao, Zhanzheng
AU - Pickering, Karen
AU - Baker, John
AU - Cutfield, Richard
AU - Orr-Walker, Brandon J.
AU - Sundborn, Gerhard
AU - Cai, Yamei
AU - Wang, Zheng
AU - Wang, Chengzeng
AU - Simmons, David
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2024.
PY - 2024/12/4
Y1 - 2024/12/4
N2 - INTRODUCTION: To evaluate the long-term risk of developing type 2 diabetes (T2D) among women with a history of gestational diabetes mellitus (GDM) compared with those with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS: Using data from a primary care dataset linked with multiple health registries, this longitudinal study analyzed demographics, clinical data, and lifestyle factors of women diagnosed with GDM or IGT, assessing T2D incidence over 25 years, using Cox regression models. RESULTS: Women with GDM, especially those over 35 years of Māori ethnicity, or socioeconomic deprivation, exhibited an elevated risk of T2D compared with those with IGT. The first 5 years post partum emerged as a critical window for intervention. CONCLUSIONS: This study underscores the importance of early, targeted post-GDM interventions to mitigate T2D risk. It highlights the necessity of personalized post-GDM interventions to reduce T2D incidence which consider age, ethnicity, and socioeconomic status to maximize effectiveness.
AB - INTRODUCTION: To evaluate the long-term risk of developing type 2 diabetes (T2D) among women with a history of gestational diabetes mellitus (GDM) compared with those with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS: Using data from a primary care dataset linked with multiple health registries, this longitudinal study analyzed demographics, clinical data, and lifestyle factors of women diagnosed with GDM or IGT, assessing T2D incidence over 25 years, using Cox regression models. RESULTS: Women with GDM, especially those over 35 years of Māori ethnicity, or socioeconomic deprivation, exhibited an elevated risk of T2D compared with those with IGT. The first 5 years post partum emerged as a critical window for intervention. CONCLUSIONS: This study underscores the importance of early, targeted post-GDM interventions to mitigate T2D risk. It highlights the necessity of personalized post-GDM interventions to reduce T2D incidence which consider age, ethnicity, and socioeconomic status to maximize effectiveness.
KW - Diabetes Mellitus, Type 2
KW - Diabetes, Gestational
KW - Healthcare Disparities
KW - Prediabetic State
UR - http://www.scopus.com/inward/record.url?scp=85211688497&partnerID=8YFLogxK
U2 - 10.1136/bmjdrc-2024-004210
DO - 10.1136/bmjdrc-2024-004210
M3 - Article
C2 - 39631843
AN - SCOPUS:85211688497
SN - 2052-4897
VL - 12
JO - BMJ Open Diabetes Research and Care
JF - BMJ Open Diabetes Research and Care
IS - 6
M1 - e004210
ER -