Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice

Saeed Shanehsazzadeh; Afsaneh Lahooti; S. P. Shirmardi; M. Erfani

doi:10.1007/s10967-015-3995-7

Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice

Saeed Shanehsazzadeh
, Afsaneh Lahooti
, S. P. Shirmardi
, M. Erfani

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

This study describes the preparation, biodistribution and absorbed dose prediction of 67Ga and 99mTc labeled bombesin (BBN) in human organs, after injection in mice determined via medical internal radiation dose. We estimated that a 185-MBq injection of 67Ga-BBN into the humans would result in an estimated effective absorbed dose of 2.50 mSv whereas this value for 99mTc-BBN is 1.33 mSv in the whole body. These results suggest that injection of 67Ga-BBN would result 2 times higher absorbed dose compare to 99mTc-BBN.

Original language	English
Pages (from-to)	513-520
Number of pages	8
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	305
Issue number	2
DOIs	https://doi.org/10.1007/s10967-015-3995-7
Publication status	Published - 2015

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10.1007/s10967-015-3995-7

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title = "Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice",

abstract = "This study describes the preparation, biodistribution and absorbed dose prediction of 67Ga and 99mTc labeled bombesin (BBN) in human organs, after injection in mice determined via medical internal radiation dose. We estimated that a 185-MBq injection of 67Ga-BBN into the humans would result in an estimated effective absorbed dose of 2.50 mSv whereas this value for 99mTc-BBN is 1.33 mSv in the whole body. These results suggest that injection of 67Ga-BBN would result 2 times higher absorbed dose compare to 99mTc-BBN.",

author = "Saeed Shanehsazzadeh and Afsaneh Lahooti and Shirmardi, \{S. P.\} and M. Erfani",

year = "2015",

doi = "10.1007/s10967-015-3995-7",

language = "English",

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T1 - Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice

AU - Shanehsazzadeh, Saeed

AU - Lahooti, Afsaneh

AU - Shirmardi, S. P.

AU - Erfani, M.

PY - 2015

Y1 - 2015

N2 - This study describes the preparation, biodistribution and absorbed dose prediction of 67Ga and 99mTc labeled bombesin (BBN) in human organs, after injection in mice determined via medical internal radiation dose. We estimated that a 185-MBq injection of 67Ga-BBN into the humans would result in an estimated effective absorbed dose of 2.50 mSv whereas this value for 99mTc-BBN is 1.33 mSv in the whole body. These results suggest that injection of 67Ga-BBN would result 2 times higher absorbed dose compare to 99mTc-BBN.

AB - This study describes the preparation, biodistribution and absorbed dose prediction of 67Ga and 99mTc labeled bombesin (BBN) in human organs, after injection in mice determined via medical internal radiation dose. We estimated that a 185-MBq injection of 67Ga-BBN into the humans would result in an estimated effective absorbed dose of 2.50 mSv whereas this value for 99mTc-BBN is 1.33 mSv in the whole body. These results suggest that injection of 67Ga-BBN would result 2 times higher absorbed dose compare to 99mTc-BBN.

UR - https://hdl.handle.net/1959.7/uws:76304

U2 - 10.1007/s10967-015-3995-7

DO - 10.1007/s10967-015-3995-7

M3 - Article

SN - 0236-5731

VL - 305

SP - 513

EP - 520

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 2

ER -

Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice

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