Complications of antenatal corticosteroids in infants born by early term scheduled cesarean section

Katharine Gupta; Rohit Rajagopal; Felicia King; David Simmons

doi:10.2337/dc19-2126

Complications of antenatal corticosteroids in infants born by early term scheduled cesarean section

Katharine Gupta, Rohit Rajagopal, Felicia King, David Simmons

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

OBJECTIVE To compare neonatal hypoglycemia and respiratory morbidity rates in pregnancies complicated by diabetes following early term scheduled cesarean section (ETSCS) with and without maternal corticosteroid administration. RESEARCH DESIGN AND METHODS In a retrospective cohort study, women with any form of diabetes in pregnancy undergoing ETSCS were included. Primary outcomes were admission rates to the neonatal intensive care unit (NICU) for respiratory distress syndrome (RDS)/ transient tachypnea of the newborn (TTN) and/or neonatal hypoglycemia. RESULTS NICU admission rates for neonatal hypoglycemia were significantly higher (24.2% vs. 4.4%, P 5 0.003) and RDS/TTN rates were nonsignificantly higher (15.2% vs. 7.2%, P 5 0.209) following corticosteroid administration. CONCLUSIONS Corticosteroids were not beneficial among women with any form of diabetes in pregnancy undergoing ETSCS and, indeed, may be harmful. In our hospital, we have ceased the use of corticosteroids for women under these circumstances.

Original language	English
Pages (from-to)	906-908
Number of pages	3
Journal	Diabetes Care
Volume	43
Issue number	4
DOIs	https://doi.org/10.2337/dc19-2126
Publication status	Published - 1 Apr 2020

Bibliographical note

Publisher Copyright:
© 2020 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

Keywords

cesarean section
complications
premature infants

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10.2337/dc19-2126

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title = "Complications of antenatal corticosteroids in infants born by early term scheduled cesarean section",

abstract = "OBJECTIVE To compare neonatal hypoglycemia and respiratory morbidity rates in pregnancies complicated by diabetes following early term scheduled cesarean section (ETSCS) with and without maternal corticosteroid administration. RESEARCH DESIGN AND METHODS In a retrospective cohort study, women with any form of diabetes in pregnancy undergoing ETSCS were included. Primary outcomes were admission rates to the neonatal intensive care unit (NICU) for respiratory distress syndrome (RDS)/ transient tachypnea of the newborn (TTN) and/or neonatal hypoglycemia. RESULTS NICU admission rates for neonatal hypoglycemia were significantly higher (24.2% vs. 4.4%, P 5 0.003) and RDS/TTN rates were nonsignificantly higher (15.2% vs. 7.2%, P 5 0.209) following corticosteroid administration. CONCLUSIONS Corticosteroids were not beneficial among women with any form of diabetes in pregnancy undergoing ETSCS and, indeed, may be harmful. In our hospital, we have ceased the use of corticosteroids for women under these circumstances.",

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author = "Katharine Gupta and Rohit Rajagopal and Felicia King and David Simmons",

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T1 - Complications of antenatal corticosteroids in infants born by early term scheduled cesarean section

AU - Gupta, Katharine

AU - Rajagopal, Rohit

AU - King, Felicia

AU - Simmons, David

N1 - Publisher Copyright: © 2020 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - OBJECTIVE To compare neonatal hypoglycemia and respiratory morbidity rates in pregnancies complicated by diabetes following early term scheduled cesarean section (ETSCS) with and without maternal corticosteroid administration. RESEARCH DESIGN AND METHODS In a retrospective cohort study, women with any form of diabetes in pregnancy undergoing ETSCS were included. Primary outcomes were admission rates to the neonatal intensive care unit (NICU) for respiratory distress syndrome (RDS)/ transient tachypnea of the newborn (TTN) and/or neonatal hypoglycemia. RESULTS NICU admission rates for neonatal hypoglycemia were significantly higher (24.2% vs. 4.4%, P 5 0.003) and RDS/TTN rates were nonsignificantly higher (15.2% vs. 7.2%, P 5 0.209) following corticosteroid administration. CONCLUSIONS Corticosteroids were not beneficial among women with any form of diabetes in pregnancy undergoing ETSCS and, indeed, may be harmful. In our hospital, we have ceased the use of corticosteroids for women under these circumstances.

AB - OBJECTIVE To compare neonatal hypoglycemia and respiratory morbidity rates in pregnancies complicated by diabetes following early term scheduled cesarean section (ETSCS) with and without maternal corticosteroid administration. RESEARCH DESIGN AND METHODS In a retrospective cohort study, women with any form of diabetes in pregnancy undergoing ETSCS were included. Primary outcomes were admission rates to the neonatal intensive care unit (NICU) for respiratory distress syndrome (RDS)/ transient tachypnea of the newborn (TTN) and/or neonatal hypoglycemia. RESULTS NICU admission rates for neonatal hypoglycemia were significantly higher (24.2% vs. 4.4%, P 5 0.003) and RDS/TTN rates were nonsignificantly higher (15.2% vs. 7.2%, P 5 0.209) following corticosteroid administration. CONCLUSIONS Corticosteroids were not beneficial among women with any form of diabetes in pregnancy undergoing ETSCS and, indeed, may be harmful. In our hospital, we have ceased the use of corticosteroids for women under these circumstances.

KW - cesarean section

KW - complications

KW - premature infants

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DO - 10.2337/dc19-2126

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SN - 0149-5992

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SP - 906

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JO - Diabetes Care

JF - Diabetes Care

IS - 4

ER -

Complications of antenatal corticosteroids in infants born by early term scheduled cesarean section

Abstract

Bibliographical note

Keywords

UN SDGs

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