Controlled diffusion of photoswitchable receptors by binding anti-electrostatic hydrogen-bonded phosphate oligomers

Thomas S. C. MacDonald; Ben L. Feringa; William S. Price; Sander J. Wezenberg; Jonathon E. Beves

doi:10.1021/jacs.0c09072

Controlled diffusion of photoswitchable receptors by binding anti-electrostatic hydrogen-bonded phosphate oligomers

Thomas S. C. MacDonald
, Ben L. Feringa
, William S. Price
, Sander J. Wezenberg
, Jonathon E. Beves

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Dihydrogen phosphate anions are found to spontaneously associate into anti-electrostatic oligomers via hydrogen bonding interactions at millimolar concentrations in DMSO. Diffusion NMR measurements supported formation of these oligomers, which can be bound by photoswitchable anion receptors to form large bridged assemblies of approximately three times the volume of the unbound receptor. Photoisomerization of the oligomer-bound receptor causes a decrease in diffusion coefficient of up to 16%, corresponding to a 70% increase in effective volume. This new approach to external control of diffusion opens prospects in controlling molecular transport using light.

Original language	English
Pages (from-to)	20014-20020
Number of pages	7
Journal	Journal of the American Chemical Society
Volume	142
Issue number	47
DOIs	https://doi.org/10.1021/jacs.0c09072
Publication status	Published - 25 Nov 2020

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© 2020 American Chemical Society.

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This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.

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title = "Controlled diffusion of photoswitchable receptors by binding anti-electrostatic hydrogen-bonded phosphate oligomers",

abstract = "Dihydrogen phosphate anions are found to spontaneously associate into anti-electrostatic oligomers via hydrogen bonding interactions at millimolar concentrations in DMSO. Diffusion NMR measurements supported formation of these oligomers, which can be bound by photoswitchable anion receptors to form large bridged assemblies of approximately three times the volume of the unbound receptor. Photoisomerization of the oligomer-bound receptor causes a decrease in diffusion coefficient of up to 16\%, corresponding to a 70\% increase in effective volume. This new approach to external control of diffusion opens prospects in controlling molecular transport using light.",

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AU - MacDonald, Thomas S. C.

AU - Feringa, Ben L.

AU - Price, William S.

AU - Wezenberg, Sander J.

AU - Beves, Jonathon E.

PY - 2020/11/25

Y1 - 2020/11/25

N2 - Dihydrogen phosphate anions are found to spontaneously associate into anti-electrostatic oligomers via hydrogen bonding interactions at millimolar concentrations in DMSO. Diffusion NMR measurements supported formation of these oligomers, which can be bound by photoswitchable anion receptors to form large bridged assemblies of approximately three times the volume of the unbound receptor. Photoisomerization of the oligomer-bound receptor causes a decrease in diffusion coefficient of up to 16%, corresponding to a 70% increase in effective volume. This new approach to external control of diffusion opens prospects in controlling molecular transport using light.

AB - Dihydrogen phosphate anions are found to spontaneously associate into anti-electrostatic oligomers via hydrogen bonding interactions at millimolar concentrations in DMSO. Diffusion NMR measurements supported formation of these oligomers, which can be bound by photoswitchable anion receptors to form large bridged assemblies of approximately three times the volume of the unbound receptor. Photoisomerization of the oligomer-bound receptor causes a decrease in diffusion coefficient of up to 16%, corresponding to a 70% increase in effective volume. This new approach to external control of diffusion opens prospects in controlling molecular transport using light.

UR - https://hdl.handle.net/1959.7/uws:61881

U2 - 10.1021/jacs.0c09072

DO - 10.1021/jacs.0c09072

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EP - 20020

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 47

ER -

Controlled diffusion of photoswitchable receptors by binding anti-electrostatic hydrogen-bonded phosphate oligomers

Abstract

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