Costatamins A - C, new 4-phenylcoumarins with anti-inflammatory activity from the Australian woodland tree Angophora costata (Myrtaceae)

Ritesh Raju; Ahilya Singh; Frances Bodkin; Gerald Munch

doi:10.1016/j.fitote.2019.01.004

Costatamins A - C, new 4-phenylcoumarins with anti-inflammatory activity from the Australian woodland tree Angophora costata (Myrtaceae)

Ritesh Raju, Ahilya Singh, Frances Bodkin, Gerald Munch

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

The bioassay guided isolation of new anti-inflammatory metabolites from the Australian Indigenous plant Angophora costata, led to the discovery of three new 4-phenylcoumarins, costatamins A – C (1–3). The structures were determined by detailed spectroscopic analysis. Costatamins A – C were evaluated for their inhibitory effects on (a) NO production and (b) downregulation of TNF-α in RAW 264.7 macrophages, displaying an inhibitory range of 20–30 μg/mL for both the inflammatory markers.

Original language	English
Article number	FITOTE 4068
Pages (from-to)	171-174
Number of pages	16
Journal	Fitoterapia
Volume	133
DOIs	https://doi.org/10.1016/j.fitote.2019.01.004
Publication status	Published - 2019

Keywords

Australia
Myrtaceae
anti-inflammatory agents
forest plants
tumor necrosis factor

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10.1016/j.fitote.2019.01.004

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title = "Costatamins A - C, new 4-phenylcoumarins with anti-inflammatory activity from the Australian woodland tree Angophora costata (Myrtaceae)",

abstract = "The bioassay guided isolation of new anti-inflammatory metabolites from the Australian Indigenous plant Angophora costata, led to the discovery of three new 4-phenylcoumarins, costatamins A – C (1–3). The structures were determined by detailed spectroscopic analysis. Costatamins A – C were evaluated for their inhibitory effects on (a) NO production and (b) downregulation of TNF-α in RAW 264.7 macrophages, displaying an inhibitory range of 20–30 μg/mL for both the inflammatory markers.",

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language = "English",

volume = "133",

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journal = "Fitoterapia",

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AU - Raju, Ritesh

AU - Singh, Ahilya

AU - Bodkin, Frances

AU - Munch, Gerald

PY - 2019

Y1 - 2019

N2 - The bioassay guided isolation of new anti-inflammatory metabolites from the Australian Indigenous plant Angophora costata, led to the discovery of three new 4-phenylcoumarins, costatamins A – C (1–3). The structures were determined by detailed spectroscopic analysis. Costatamins A – C were evaluated for their inhibitory effects on (a) NO production and (b) downregulation of TNF-α in RAW 264.7 macrophages, displaying an inhibitory range of 20–30 μg/mL for both the inflammatory markers.

AB - The bioassay guided isolation of new anti-inflammatory metabolites from the Australian Indigenous plant Angophora costata, led to the discovery of three new 4-phenylcoumarins, costatamins A – C (1–3). The structures were determined by detailed spectroscopic analysis. Costatamins A – C were evaluated for their inhibitory effects on (a) NO production and (b) downregulation of TNF-α in RAW 264.7 macrophages, displaying an inhibitory range of 20–30 μg/mL for both the inflammatory markers.

KW - Australia

KW - Myrtaceae

KW - anti-inflammatory agents

KW - forest plants

KW - tumor necrosis factor

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:49426

U2 - 10.1016/j.fitote.2019.01.004

DO - 10.1016/j.fitote.2019.01.004

M3 - Article

SN - 0367-326X

VL - 133

SP - 171

EP - 174

JO - Fitoterapia

JF - Fitoterapia

M1 - FITOTE 4068

ER -

Costatamins A - C, new 4-phenylcoumarins with anti-inflammatory activity from the Australian woodland tree Angophora costata (Myrtaceae)

Abstract

Keywords

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