Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: Synthesis and reactivity of substituted maleimides

Joseph I. Ambrus; Jill I. Halliday; Nicholas Kanizaj; Nathan Absalom; Kasper Harpsøe; Thomas Balle; Mary Chebib; Malcolm D. McLeod

doi:10.1039/c2cc32442c

Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: Synthesis and reactivity of substituted maleimides

Joseph I. Ambrus
, Jill I. Halliday
, Nicholas Kanizaj
, Nathan Absalom
, Kasper Harpsøe
, Thomas Balle
, Mary Chebib
, Malcolm D. McLeod

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

Original language	English
Pages (from-to)	6699-6701
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	53
DOIs	https://doi.org/10.1039/c2cc32442c
Publication status	Published - 6 Jun 2012
Externally published	Yes

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title = "Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: Synthesis and reactivity of substituted maleimides",

abstract = "The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).",

author = "Ambrus, \{Joseph I.\} and Halliday, \{Jill I.\} and Nicholas Kanizaj and Nathan Absalom and Kasper Harps{\o}e and Thomas Balle and Mary Chebib and McLeod, \{Malcolm D.\}",

year = "2012",

month = jun,

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doi = "10.1039/c2cc32442c",

language = "English",

volume = "48",

pages = "6699--6701",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor

T2 - Synthesis and reactivity of substituted maleimides

AU - Ambrus, Joseph I.

AU - Halliday, Jill I.

AU - Kanizaj, Nicholas

AU - Absalom, Nathan

AU - Harpsøe, Kasper

AU - Balle, Thomas

AU - Chebib, Mary

AU - McLeod, Malcolm D.

PY - 2012/6/6

Y1 - 2012/6/6

N2 - The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

AB - The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

UR - https://www.scopus.com/pages/publications/84862206627

U2 - 10.1039/c2cc32442c

DO - 10.1039/c2cc32442c

M3 - Article

C2 - 22627701

AN - SCOPUS:84862206627

SN - 1359-7345

VL - 48

SP - 6699

EP - 6701

JO - Chemical Communications

JF - Chemical Communications

IS - 53

ER -

Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: Synthesis and reactivity of substituted maleimides

Abstract

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