CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC

Ling Bi; Chanlu Xie; Lijing Jiao; Shenyi Jin; Su Su Thae Hnit; Yao Mu; Yilun Wang; Qian Wang; Guangbo Ge; Yaqiao Wang; Xiaodong Zhao; Xinglong Shi; Yani Kang; Paul De Souza; Tao Liu; Jia Zhou; Ling Xu; Qihan Dong

doi:10.1111/jcmm.14897

CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC

Ling Bi, Chanlu Xie, Lijing Jiao, Shenyi Jin, Su Su Thae Hnit, Yao Mu, Yilun Wang, Qian Wang, Guangbo Ge, Yaqiao Wang, Xiaodong Zhao, Xinglong Shi, Yani Kang, Paul De Souza, Tao Liu, Jia Zhou, Ling Xu, Qihan Dong

Western Sydney University

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence.

Original language	English
Pages (from-to)	2229-2239
Number of pages	11
Journal	Journal of Cellular and Molecular Medicine
Volume	24
Issue number	3
DOIs	https://doi.org/10.1111/jcmm.14897
Publication status	Published - 2020

Open Access - Access Right Statement

© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Keywords

cancer
lungs

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jcmm.14897

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Bi, L., Xie, C., Jiao, L., Jin, S., Hnit, S. S. T., Mu, Y., Wang, Y., Wang, Q., Ge, G., Wang, Y., Zhao, X., Shi, X., Kang, Y., De Souza, P., Liu, T., Zhou, J., Xu, L., & Dong, Q. (2020). CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC. Journal of Cellular and Molecular Medicine, 24(3), 2229-2239. https://doi.org/10.1111/jcmm.14897

@article{cf948ea503754befbee62187f4b80a23,

title = "CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC",

abstract = "Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence.",

keywords = "cancer, lungs",

author = "Ling Bi and Chanlu Xie and Lijing Jiao and Shenyi Jin and Hnit, {Su Su Thae} and Yao Mu and Yilun Wang and Qian Wang and Guangbo Ge and Yaqiao Wang and Xiaodong Zhao and Xinglong Shi and Yani Kang and {De Souza}, Paul and Tao Liu and Jia Zhou and Ling Xu and Qihan Dong",

year = "2020",

doi = "10.1111/jcmm.14897",

language = "English",

volume = "24",

pages = "2229--2239",

journal = "Journal of Cellular and Molecular Medicine",

issn = "1582-1838",

publisher = "Wiley-Blackwell Publishing",

number = "3",

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Bi, L, Xie, C, Jiao, L, Jin, S, Hnit, SST, Mu, Y, Wang, Y, Wang, Q, Ge, G, Wang, Y, Zhao, X, Shi, X, Kang, Y, De Souza, P, Liu, T, Zhou, J, Xu, L & Dong, Q 2020, 'CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC', Journal of Cellular and Molecular Medicine, vol. 24, no. 3, pp. 2229-2239. https://doi.org/10.1111/jcmm.14897

TY - JOUR

T1 - CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC

AU - Bi, Ling

AU - Xie, Chanlu

AU - Jiao, Lijing

AU - Jin, Shenyi

AU - Hnit, Su Su Thae

AU - Mu, Yao

AU - Wang, Yilun

AU - Wang, Qian

AU - Ge, Guangbo

AU - Wang, Yaqiao

AU - Zhao, Xiaodong

AU - Shi, Xinglong

AU - Kang, Yani

AU - De Souza, Paul

AU - Liu, Tao

AU - Zhou, Jia

AU - Xu, Ling

AU - Dong, Qihan

PY - 2020

Y1 - 2020

N2 - Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence.

AB - Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence.

KW - cancer

KW - lungs

UR - https://hdl.handle.net/1959.7/uws:55105

U2 - 10.1111/jcmm.14897

DO - 10.1111/jcmm.14897

M3 - Article

SN - 1582-1838

VL - 24

SP - 2229

EP - 2239

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

IS - 3

ER -

CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC

Abstract

Open Access - Access Right Statement

Keywords

UN SDGs

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