Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland

R. S. Patel; C. W. Hughes; S. Fredericks; C. S. Lee; B. Rose; K. Gao; G. Smith; A. Hong; C. J. O'Brien

doi:10.1111/j.1365-2559.2007.02729.x

Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland

R. S. Patel, C. W. Hughes, S. Fredericks, C. S. Lee, B. Rose, K. Gao, G. Smith, A. Hong, C. J. O'Brien

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Aims: To investigate cyclin A expression in pleomorphic adenoma (PA) and carcinoma expleomorphic adenoma (CXPA) of the parotid gland with a view to assessing its potential value as a diagnostic marker for CXPA. Methods and results: Cyclin A expression in PA and CXPA was studied using semiquantitiative immunohistochemistry. The epithelial component of the tumours expressed cyclin A in a statistically significantly (P < 0.005) higher number of CXPA cases (86%) compared with the PA cases (39%). Cyclin A was not expressed in normal salivary tissues of PA and CXPA. Conclusions: High cyclin A expression is a useful marker for the pathological diagnosis of CXPA.

Original language	English
Pages (from-to)	21-25
Number of pages	5
Journal	Histopathology
Volume	51
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2559.2007.02729.x
Publication status	Published - Jul 2007
Externally published	Yes

Keywords

Carcinoma expleomorphic adenoma
Cyclin A
Immunohistochemistry
Pleomorphic adenoma
Salivary gland tumour

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-2559.2007.02729.x

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title = "Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland",

abstract = "Aims: To investigate cyclin A expression in pleomorphic adenoma (PA) and carcinoma expleomorphic adenoma (CXPA) of the parotid gland with a view to assessing its potential value as a diagnostic marker for CXPA. Methods and results: Cyclin A expression in PA and CXPA was studied using semiquantitiative immunohistochemistry. The epithelial component of the tumours expressed cyclin A in a statistically significantly (P < 0.005) higher number of CXPA cases (86%) compared with the PA cases (39%). Cyclin A was not expressed in normal salivary tissues of PA and CXPA. Conclusions: High cyclin A expression is a useful marker for the pathological diagnosis of CXPA.",

keywords = "Carcinoma expleomorphic adenoma, Cyclin A, Immunohistochemistry, Pleomorphic adenoma, Salivary gland tumour",

author = "Patel, {R. S.} and Hughes, {C. W.} and S. Fredericks and Lee, {C. S.} and B. Rose and K. Gao and G. Smith and A. Hong and O'Brien, {C. J.}",

year = "2007",

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journal = "Histopathology",

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T1 - Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland

AU - Patel, R. S.

AU - Hughes, C. W.

AU - Fredericks, S.

AU - Lee, C. S.

AU - Rose, B.

AU - Gao, K.

AU - Smith, G.

AU - Hong, A.

AU - O'Brien, C. J.

PY - 2007/7

Y1 - 2007/7

N2 - Aims: To investigate cyclin A expression in pleomorphic adenoma (PA) and carcinoma expleomorphic adenoma (CXPA) of the parotid gland with a view to assessing its potential value as a diagnostic marker for CXPA. Methods and results: Cyclin A expression in PA and CXPA was studied using semiquantitiative immunohistochemistry. The epithelial component of the tumours expressed cyclin A in a statistically significantly (P < 0.005) higher number of CXPA cases (86%) compared with the PA cases (39%). Cyclin A was not expressed in normal salivary tissues of PA and CXPA. Conclusions: High cyclin A expression is a useful marker for the pathological diagnosis of CXPA.

AB - Aims: To investigate cyclin A expression in pleomorphic adenoma (PA) and carcinoma expleomorphic adenoma (CXPA) of the parotid gland with a view to assessing its potential value as a diagnostic marker for CXPA. Methods and results: Cyclin A expression in PA and CXPA was studied using semiquantitiative immunohistochemistry. The epithelial component of the tumours expressed cyclin A in a statistically significantly (P < 0.005) higher number of CXPA cases (86%) compared with the PA cases (39%). Cyclin A was not expressed in normal salivary tissues of PA and CXPA. Conclusions: High cyclin A expression is a useful marker for the pathological diagnosis of CXPA.

KW - Carcinoma expleomorphic adenoma

KW - Cyclin A

KW - Immunohistochemistry

KW - Pleomorphic adenoma

KW - Salivary gland tumour

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U2 - 10.1111/j.1365-2559.2007.02729.x

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AN - SCOPUS:34250852463

SN - 0309-0167

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JO - Histopathology

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Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland

Abstract

Keywords

UN SDGs

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