TY - JOUR
T1 - Deciphering signaling pathways in hematopoietic stem cells
T2 - the molecular complexity of Myelodysplastic Syndromes (MDS) and leukemic progression
AU - Casalin, Irene
AU - De Stefano, Alessia
AU - Ceneri, Eleonora
AU - Cappellini, Alessandra
AU - Finelli, Carlo
AU - Curti, Antonio
AU - Paolini, Stefania
AU - Parisi, Sarah
AU - Zannoni, Letizia
AU - Boultwood, Jacqueline
AU - McCubrey, James A.
AU - Suh, Pann Ghill
AU - Ramazzotti, Giulia
AU - Fiume, Roberta
AU - Ratti, Stefano
AU - Manzoli, Lucia
AU - Cocco, Lucio
AU - Follo, Matilde Y.
PY - 2024/1
Y1 - 2024/1
N2 - Myelodysplastic Syndromes, a heterogeneous group of hematological disorders, are characterized by abnormalities in phosphoinositide-dependent signaling, epigenetic regulators, apoptosis, and cytokine interactions within the bone marrow microenvironment, contributing to disease pathogenesis and neoplastic growth. Comprehensive knowledge of these pathways is crucial for the development of innovative therapies that aim to restore normal apoptosis and improve patient outcomes.
AB - Myelodysplastic Syndromes, a heterogeneous group of hematological disorders, are characterized by abnormalities in phosphoinositide-dependent signaling, epigenetic regulators, apoptosis, and cytokine interactions within the bone marrow microenvironment, contributing to disease pathogenesis and neoplastic growth. Comprehensive knowledge of these pathways is crucial for the development of innovative therapies that aim to restore normal apoptosis and improve patient outcomes.
KW - Acute myeloid leukemia
KW - Apoptosis
KW - Cytokines secretion
KW - Epigenetic regulation
KW - Myelodysplastic Syndromes
KW - Phosphoinositide signaling
UR - http://www.scopus.com/inward/record.url?scp=85183176429&partnerID=8YFLogxK
U2 - 10.1016/j.jbior.2024.101014
DO - 10.1016/j.jbior.2024.101014
M3 - Article
C2 - 38242820
AN - SCOPUS:85183176429
SN - 2212-4926
VL - 91
JO - Advances in Biological Regulation
JF - Advances in Biological Regulation
M1 - 101014
ER -
