Deciphering signaling pathways in hematopoietic stem cells: the molecular complexity of Myelodysplastic Syndromes (MDS) and leukemic progression

Irene Casalin; Alessia De Stefano; Eleonora Ceneri; Alessandra Cappellini; Carlo Finelli; Antonio Curti; Stefania Paolini; Sarah Parisi; Letizia Zannoni; Jacqueline Boultwood; James A. McCubrey; Pann Ghill Suh; Giulia Ramazzotti; Roberta Fiume; Stefano Ratti; Lucia Manzoli; Lucio Cocco; Matilde Y. Follo

doi:10.1016/j.jbior.2024.101014

Deciphering signaling pathways in hematopoietic stem cells: the molecular complexity of Myelodysplastic Syndromes (MDS) and leukemic progression

Irene Casalin
, Alessia De Stefano
, Eleonora Ceneri
, Alessandra Cappellini
, Carlo Finelli
, Antonio Curti
, Stefania Paolini
, Sarah Parisi
, Letizia Zannoni
, Jacqueline Boultwood
, James A. McCubrey
, Pann Ghill Suh
, Giulia Ramazzotti
, Roberta Fiume
, Stefano Ratti
, Lucia Manzoli
, Lucio Cocco
, Matilde Y. Follo

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

10 Downloads (Pure)

Abstract

Myelodysplastic Syndromes, a heterogeneous group of hematological disorders, are characterized by abnormalities in phosphoinositide-dependent signaling, epigenetic regulators, apoptosis, and cytokine interactions within the bone marrow microenvironment, contributing to disease pathogenesis and neoplastic growth. Comprehensive knowledge of these pathways is crucial for the development of innovative therapies that aim to restore normal apoptosis and improve patient outcomes.

Original language	English
Article number	101014
Number of pages	8
Journal	Advances in Biological Regulation
Volume	91
DOIs	https://doi.org/10.1016/j.jbior.2024.101014
Publication status	Published - Jan 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute myeloid leukemia
Apoptosis
Cytokines secretion
Epigenetic regulation
Myelodysplastic Syndromes
Phosphoinositide signaling

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10.1016/j.jbior.2024.101014Licence: CC BY

full textFinal published version, 1.67 MBLicence: CC BY

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Casalin, I., De Stefano, A., Ceneri, E., Cappellini, A., Finelli, C., Curti, A., Paolini, S., Parisi, S., Zannoni, L., Boultwood, J., McCubrey, J. A., Suh, P. G., Ramazzotti, G., Fiume, R., Ratti, S., Manzoli, L., Cocco, L., & Follo, M. Y. (2024). Deciphering signaling pathways in hematopoietic stem cells: the molecular complexity of Myelodysplastic Syndromes (MDS) and leukemic progression. Advances in Biological Regulation, 91, Article 101014. https://doi.org/10.1016/j.jbior.2024.101014

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title = "Deciphering signaling pathways in hematopoietic stem cells: the molecular complexity of Myelodysplastic Syndromes (MDS) and leukemic progression",

abstract = "Myelodysplastic Syndromes, a heterogeneous group of hematological disorders, are characterized by abnormalities in phosphoinositide-dependent signaling, epigenetic regulators, apoptosis, and cytokine interactions within the bone marrow microenvironment, contributing to disease pathogenesis and neoplastic growth. Comprehensive knowledge of these pathways is crucial for the development of innovative therapies that aim to restore normal apoptosis and improve patient outcomes.",

keywords = "Acute myeloid leukemia, Apoptosis, Cytokines secretion, Epigenetic regulation, Myelodysplastic Syndromes, Phosphoinositide signaling",

author = "Irene Casalin and \{De Stefano\}, Alessia and Eleonora Ceneri and Alessandra Cappellini and Carlo Finelli and Antonio Curti and Stefania Paolini and Sarah Parisi and Letizia Zannoni and Jacqueline Boultwood and McCubrey, \{James A.\} and Suh, \{Pann Ghill\} and Giulia Ramazzotti and Roberta Fiume and Stefano Ratti and Lucia Manzoli and Lucio Cocco and Follo, \{Matilde Y.\}",

year = "2024",

month = jan,

doi = "10.1016/j.jbior.2024.101014",

language = "English",

volume = "91",

journal = "Advances in Biological Regulation",

issn = "2212-4926",

publisher = "Elsevier Ltd.",

}

Casalin, I, De Stefano, A, Ceneri, E, Cappellini, A, Finelli, C, Curti, A, Paolini, S, Parisi, S, Zannoni, L, Boultwood, J, McCubrey, JA, Suh, PG, Ramazzotti, G, Fiume, R, Ratti, S, Manzoli, L, Cocco, L & Follo, MY 2024, 'Deciphering signaling pathways in hematopoietic stem cells: the molecular complexity of Myelodysplastic Syndromes (MDS) and leukemic progression', Advances in Biological Regulation, vol. 91, 101014. https://doi.org/10.1016/j.jbior.2024.101014

TY - JOUR

T1 - Deciphering signaling pathways in hematopoietic stem cells

T2 - the molecular complexity of Myelodysplastic Syndromes (MDS) and leukemic progression

AU - Casalin, Irene

AU - De Stefano, Alessia

AU - Ceneri, Eleonora

AU - Cappellini, Alessandra

AU - Finelli, Carlo

AU - Curti, Antonio

AU - Paolini, Stefania

AU - Parisi, Sarah

AU - Zannoni, Letizia

AU - Boultwood, Jacqueline

AU - McCubrey, James A.

AU - Suh, Pann Ghill

AU - Ramazzotti, Giulia

AU - Fiume, Roberta

AU - Ratti, Stefano

AU - Manzoli, Lucia

AU - Cocco, Lucio

AU - Follo, Matilde Y.

PY - 2024/1

Y1 - 2024/1

N2 - Myelodysplastic Syndromes, a heterogeneous group of hematological disorders, are characterized by abnormalities in phosphoinositide-dependent signaling, epigenetic regulators, apoptosis, and cytokine interactions within the bone marrow microenvironment, contributing to disease pathogenesis and neoplastic growth. Comprehensive knowledge of these pathways is crucial for the development of innovative therapies that aim to restore normal apoptosis and improve patient outcomes.

AB - Myelodysplastic Syndromes, a heterogeneous group of hematological disorders, are characterized by abnormalities in phosphoinositide-dependent signaling, epigenetic regulators, apoptosis, and cytokine interactions within the bone marrow microenvironment, contributing to disease pathogenesis and neoplastic growth. Comprehensive knowledge of these pathways is crucial for the development of innovative therapies that aim to restore normal apoptosis and improve patient outcomes.

KW - Acute myeloid leukemia

KW - Apoptosis

KW - Cytokines secretion

KW - Epigenetic regulation

KW - Myelodysplastic Syndromes

KW - Phosphoinositide signaling

UR - https://www.scopus.com/pages/publications/85183176429

U2 - 10.1016/j.jbior.2024.101014

DO - 10.1016/j.jbior.2024.101014

M3 - Article

C2 - 38242820

AN - SCOPUS:85183176429

SN - 2212-4926

VL - 91

JO - Advances in Biological Regulation

JF - Advances in Biological Regulation

M1 - 101014

ER -

Deciphering signaling pathways in hematopoietic stem cells: the molecular complexity of Myelodysplastic Syndromes (MDS) and leukemic progression

Abstract

UN SDGs

Keywords

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