Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect

Jeroen A. C. M. Goos; Andrew Cho; Lukas M. Carter; Thomas R. Dilling; Maria Davydova; Komal Mandleywala; Simon Puttick; Abhishek Gupta; William S. Price; John F. Quinn; Michael R. Whittaker; Jason S. Lewis; Thomas P. Davis

doi:10.7150/thno.36777

Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect

Jeroen A. C. M. Goos, Andrew Cho, Lukas M. Carter, Thomas R. Dilling, Maria Davydova, Komal Mandleywala, Simon Puttick, Abhishek Gupta, William S. Price, John F. Quinn, Michael R. Whittaker, Jason S. Lewis, Thomas P. Davis

Western Sydney University

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Expression levels of biomarkers are generally unknown at initial diagnosis. The development of theranostic probes that do not rely on biomarker availability would expand therapy options for cancer patients, improve patient selection for nanomedicine and facilitate treatment of inoperable patients or patients with acquired therapy resistance. Herein, we report the development of star polymers, also known as nanostars, that allow for molecular imaging and/or endoradiotherapy based on passive targeting via the enhanced permeability and retention (EPR) effect.

Original language	English
Pages (from-to)	567-584
Number of pages	18
Journal	Theranostics
Volume	10
Issue number	2
DOIs	https://doi.org/10.7150/thno.36777
Publication status	Published - 2020

Open Access - Access Right Statement

© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

Keywords

biochemical markers
magnetic resonance imaging
nanoparticles
star-branched polymers
tumors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.7150/thno.36777

Cite this

Goos, J. A. C. M., Cho, A., Carter, L. M., Dilling, T. R., Davydova, M., Mandleywala, K., Puttick, S., Gupta, A., Price, W. S., Quinn, J. F., Whittaker, M. R., Lewis, J. S., & Davis, T. P. (2020). Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect. Theranostics, 10(2), 567-584. https://doi.org/10.7150/thno.36777

@article{93e4fb5419e54da0bea52b6c33f7f1ac,

title = "Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect",

abstract = "Expression levels of biomarkers are generally unknown at initial diagnosis. The development of theranostic probes that do not rely on biomarker availability would expand therapy options for cancer patients, improve patient selection for nanomedicine and facilitate treatment of inoperable patients or patients with acquired therapy resistance. Herein, we report the development of star polymers, also known as nanostars, that allow for molecular imaging and/or endoradiotherapy based on passive targeting via the enhanced permeability and retention (EPR) effect.",

keywords = "biochemical markers, magnetic resonance imaging, nanoparticles, star-branched polymers, tumors",

author = "Goos, {Jeroen A. C. M.} and Andrew Cho and Carter, {Lukas M.} and Dilling, {Thomas R.} and Maria Davydova and Komal Mandleywala and Simon Puttick and Abhishek Gupta and Price, {William S.} and Quinn, {John F.} and Whittaker, {Michael R.} and Lewis, {Jason S.} and Davis, {Thomas P.}",

year = "2020",

doi = "10.7150/thno.36777",

language = "English",

volume = "10",

pages = "567--584",

journal = "Theranostics",

issn = "1838-7640",

publisher = "Ivyspring International Publisher",

number = "2",

}

Goos, JACM, Cho, A, Carter, LM, Dilling, TR, Davydova, M, Mandleywala, K, Puttick, S, Gupta, A, Price, WS, Quinn, JF, Whittaker, MR, Lewis, JS & Davis, TP 2020, 'Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect', Theranostics, vol. 10, no. 2, pp. 567-584. https://doi.org/10.7150/thno.36777

TY - JOUR

T1 - Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect

AU - Goos, Jeroen A. C. M.

AU - Cho, Andrew

AU - Carter, Lukas M.

AU - Dilling, Thomas R.

AU - Davydova, Maria

AU - Mandleywala, Komal

AU - Puttick, Simon

AU - Gupta, Abhishek

AU - Price, William S.

AU - Quinn, John F.

AU - Whittaker, Michael R.

AU - Lewis, Jason S.

AU - Davis, Thomas P.

PY - 2020

Y1 - 2020

N2 - Expression levels of biomarkers are generally unknown at initial diagnosis. The development of theranostic probes that do not rely on biomarker availability would expand therapy options for cancer patients, improve patient selection for nanomedicine and facilitate treatment of inoperable patients or patients with acquired therapy resistance. Herein, we report the development of star polymers, also known as nanostars, that allow for molecular imaging and/or endoradiotherapy based on passive targeting via the enhanced permeability and retention (EPR) effect.

AB - Expression levels of biomarkers are generally unknown at initial diagnosis. The development of theranostic probes that do not rely on biomarker availability would expand therapy options for cancer patients, improve patient selection for nanomedicine and facilitate treatment of inoperable patients or patients with acquired therapy resistance. Herein, we report the development of star polymers, also known as nanostars, that allow for molecular imaging and/or endoradiotherapy based on passive targeting via the enhanced permeability and retention (EPR) effect.

KW - biochemical markers

KW - magnetic resonance imaging

KW - nanoparticles

KW - star-branched polymers

KW - tumors

UR - https://hdl.handle.net/1959.7/uws:53592

UR - https://www.thno.org/v10p0567

U2 - 10.7150/thno.36777

DO - 10.7150/thno.36777

M3 - Article

SN - 1838-7640

VL - 10

SP - 567

EP - 584

JO - Theranostics

JF - Theranostics

IS - 2

ER -

Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect

Abstract

Open Access - Access Right Statement

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this