Detecting electroporation by assessing the time constants in the exponential response to human skin to voltage controlled impulse electrical stimulation

Sînziana I. Bîrlea, Gavin J. Corley, Nicolae M. Bîrlea, Paul P. Breen, Fabio Quondamatteo, Gearóid ÓLaighin

    Research output: Chapter in Book / Conference PaperConference Paperpeer-review

    Abstract

    ![CDATA[We propose a new method for extracting the electrical properties of human skin based on the time constant analysis of its exponential response to impulse stimulation. As a result of this analysis an adjacent finding has arisen. We have found that stratum corneum electroporation can be detected using this analysis method. We have observed that a one time-constant model is appropriate for describing the electrical properties of human skin at low amplitude applied voltages (<30V), and a two time-constant model best describes skin electrical properties at higher amplitude applied voltages (>30V). Higher voltage amplitudes (>30V) have been proven to create pores in the skin's stratum corneum which offer a new, lower resistance, pathway for the passage of current through the skin. Our data shows that when pores are formed in the stratum corneum they can be detected, in-vivo, due to the fact that a second time constant describes current flow through them.]]
    Original languageEnglish
    Title of host publicationEMBC 2009: Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine: 2-6 September, 2009, Hilton Minneapolis, Minnesota
    PublisherI.E.E.E.
    Pages1355-1358
    Number of pages4
    ISBN (Print)9781424432967
    Publication statusPublished - 2009
    EventIEEE Engineering in Medicine and Biology Society. Annual Conference -
    Duration: 30 Apr 2015 → …

    Publication series

    Name
    ISSN (Print)1557-170X

    Conference

    ConferenceIEEE Engineering in Medicine and Biology Society. Annual Conference
    Period30/04/15 → …

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