Abstract
Introduction: In this work, Sm-153-zoledronate (Sm-153-ZLD) was studied using computational chemistry methods and prepared for possible use in bone pain palliation therapy.Methods: The Sm(ZLD)(2).7H(2)O complex was synthesized and characterized in solid state using computational chemistry methods followed by Sm-153-ZLD complex production, stablity, hydroxyapatite (HA) tests and also biodictribution studies in animals were studied and used for absorbed dose determination in critical organs.Results: The Sm(ZLD)(2).7H(2)O complex was synthesized and characterized in solid state and computational chemistry methods showed that 1:1, 1:2 and 1:3 complex formation are possible in aqueous solution. Sm-153-ZLD complex was prepared with >99% radiochemical purity (ITLC, HPLC) and specific activity of 4.4 GBq/mmol. It was stable for 24h with >95% binding to HA with accumulation in rat bones and kidneys. Absorbed dose showed kidney and osteogenic tissue as critical organs.Conclusion: The Sm-153-ZLD complex data were compared to Sm-153-EDTMP and Sm-153-BPAMD.
| Original language | English |
|---|---|
| Pages (from-to) | 81-91 |
| Number of pages | 11 |
| Journal | Iranian Journal of Nuclear Medicine |
| Volume | 25 |
| Issue number | 2 |
| Publication status | Published - Jan 2017 |
| Externally published | Yes |
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