TY - JOUR
T1 - Development and assessment of 153Sm-zoledronate complex as a possible bone pain palliative agent
AU - Nikzad, Mirsaeed
AU - Jalilian, Amir Reza
AU - Shirvani-Arani, Simindokht
AU - Arabieh, Masood
AU - Shanehsazzadeh, Saeed
AU - Golchoobian, Hamid
PY - 2017/1
Y1 - 2017/1
N2 - Introduction: In this work, Sm-153-zoledronate (Sm-153-ZLD) was studied using computational chemistry methods and prepared for possible use in bone pain palliation therapy.Methods: The Sm(ZLD)(2).7H(2)O complex was synthesized and characterized in solid state using computational chemistry methods followed by Sm-153-ZLD complex production, stablity, hydroxyapatite (HA) tests and also biodictribution studies in animals were studied and used for absorbed dose determination in critical organs.Results: The Sm(ZLD)(2).7H(2)O complex was synthesized and characterized in solid state and computational chemistry methods showed that 1:1, 1:2 and 1:3 complex formation are possible in aqueous solution. Sm-153-ZLD complex was prepared with >99% radiochemical purity (ITLC, HPLC) and specific activity of 4.4 GBq/mmol. It was stable for 24h with >95% binding to HA with accumulation in rat bones and kidneys. Absorbed dose showed kidney and osteogenic tissue as critical organs.Conclusion: The Sm-153-ZLD complex data were compared to Sm-153-EDTMP and Sm-153-BPAMD.
AB - Introduction: In this work, Sm-153-zoledronate (Sm-153-ZLD) was studied using computational chemistry methods and prepared for possible use in bone pain palliation therapy.Methods: The Sm(ZLD)(2).7H(2)O complex was synthesized and characterized in solid state using computational chemistry methods followed by Sm-153-ZLD complex production, stablity, hydroxyapatite (HA) tests and also biodictribution studies in animals were studied and used for absorbed dose determination in critical organs.Results: The Sm(ZLD)(2).7H(2)O complex was synthesized and characterized in solid state and computational chemistry methods showed that 1:1, 1:2 and 1:3 complex formation are possible in aqueous solution. Sm-153-ZLD complex was prepared with >99% radiochemical purity (ITLC, HPLC) and specific activity of 4.4 GBq/mmol. It was stable for 24h with >95% binding to HA with accumulation in rat bones and kidneys. Absorbed dose showed kidney and osteogenic tissue as critical organs.Conclusion: The Sm-153-ZLD complex data were compared to Sm-153-EDTMP and Sm-153-BPAMD.
UR - https://irjnm.tums.ac.ir/article_26409_133994b6f2d7fdb02697869c46b60eee.pdf
M3 - Article
VL - 25
SP - 81
EP - 91
JO - Iranian Journal of Nuclear Medicine
JF - Iranian Journal of Nuclear Medicine
IS - 2
ER -