Development of [111In]-DTPA-buserelin for GnRH receptor studies

A.R. Jalilian; Saeed Shanehsazzadeh; M. Akhlaghi; M. Kamali-Dehghan; S. Moradkhani

doi:10.1524/ract.2010.1689

Development of [111In]-DTPA-buserelin for GnRH receptor studies

A.R. Jalilian, Saeed Shanehsazzadeh, M. Akhlaghi, M. Kamali-Dehghan, S. Moradkhani

Tehran University of Medical Sciences

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Buserelin Was successively labeled with [In-111]-Indium chloride after residuation with DTPA-dianhydride. Radio-chromatography showed an overall radiochemical purity of >90% (RTLC) and > 95% (HPLC) at optimized conditions after labeling (specific activity: 400-450GBq/M). The serum stability of the tracer was determined LIP to 24 h. The biodistribution of the tracer was determined in normal rats showing significant breast and ovaries uptakes 60 min post injection. MCF-7 cell binding of the tracer was > 98%. A significant testes uptake was demonstrated in normal male Kits using SPECT studies.

Original language	English
Pages (from-to)	113-119
Number of pages	7
Journal	Radiochimica Acta
Volume	98
Issue number	2
DOIs	https://doi.org/10.1524/ract.2010.1689
Publication status	Published - Apr 2010
Externally published	Yes

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10.1524/ract.2010.1689

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AU - Kamali-Dehghan, M.

AU - Moradkhani, S.

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Development of [111In]-DTPA-buserelin for GnRH receptor studies

Abstract

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