TY - JOUR
T1 - Development of the immune system and immunological protection in marsupial pouch young
AU - Old, J. M.
AU - Deane, E. M.
PY - 2000
Y1 - 2000
N2 - At birth the tissues of marsupial immune system are underdeveloped. The young animal is not immunocompetent. Histological and immunohistochemical studies of pouch young epithelial tissues provide a clear picture of tissue development but the timing of onset of immunocompetence awaits definition. The survival of the neonatal marsupial in a microbially rich environment is dependent on maternal strategies, including immunoglobulin transfer via milk and, in some species, prenatally via the yolk sac placenta. It is also likely that pouch secretions play a role. This review summarizes our current knowledge of the pathway of immunological development in marsupials and the protection and threats afforded by the pouch environment.
AB - At birth the tissues of marsupial immune system are underdeveloped. The young animal is not immunocompetent. Histological and immunohistochemical studies of pouch young epithelial tissues provide a clear picture of tissue development but the timing of onset of immunocompetence awaits definition. The survival of the neonatal marsupial in a microbially rich environment is dependent on maternal strategies, including immunoglobulin transfer via milk and, in some species, prenatally via the yolk sac placenta. It is also likely that pouch secretions play a role. This review summarizes our current knowledge of the pathway of immunological development in marsupials and the protection and threats afforded by the pouch environment.
UR - http://hdl.handle.net/1959.7/uws:23532
U2 - 10.1016/S0145-305X(00)00008-2
DO - 10.1016/S0145-305X(00)00008-2
M3 - Article
SN - 0145-305X
VL - 24
SP - 445
EP - 454
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
IS - 5
ER -