Diarylheptanoids with anti-inflammatory activity from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae)

Ritesh Raju; Ahilya Singh; Dhanushka Gunawardena; Paul Reddell; Gerald Münch

doi:10.1016/j.phytol.2019.01.004

Diarylheptanoids with anti-inflammatory activity from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae)

Ritesh Raju, Ahilya Singh, Dhanushka Gunawardena, Paul Reddell, Gerald Münch

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Three new metabolites, 1-(4"²"²-Methoxyphenyl)-7-(3"²,4"²-di-hydroxyphenyl)-(E)-hept-2-ene (1), 1-(4"²"²- Methoxyphenyl)-7-(3"²,4"²-di-methoxyphenyl)-(E)-hept-2-ene (2), 1-(4"²"²-Methoxyphenyl)-7-(4"²-methoxyphenyl)- (E)-hept-2-ene (3), and the known diaryl heptanoid (4) were identified following anti-inflammatory activity guided fractionation from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae). These diaryl heptanoids (1" 4) were evaluated for their inhibitory effects on NO production and downregulation of TNF-Î± in RAW 264.7 macrophages and N-11 microglial cell lines).

Original language	English
Pages (from-to)	10-13
Number of pages	4
Journal	Phytochemistry Letters
Volume	30
DOIs	https://doi.org/10.1016/j.phytol.2019.01.004
Publication status	Published - Apr 2019

Bibliographical note

Publisher Copyright:
© 2019 Phytochemical Society of Europe

Keywords

Zingiberaceae
anti-inflammatory agents
diarylheptanoids
herbs
therapeutic use

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10.1016/j.phytol.2019.01.004

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title = "Diarylheptanoids with anti-inflammatory activity from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae)",

abstract = "Three new metabolites, 1-(4{"}²{"}²-Methoxyphenyl)-7-(3{"}²,4{"}²-di-hydroxyphenyl)-(E)-hept-2-ene (1), 1-(4{"}²{"}²- Methoxyphenyl)-7-(3{"}²,4{"}²-di-methoxyphenyl)-(E)-hept-2-ene (2), 1-(4{"}²{"}²-Methoxyphenyl)-7-(4{"}²-methoxyphenyl)- (E)-hept-2-ene (3), and the known diaryl heptanoid (4) were identified following anti-inflammatory activity guided fractionation from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae). These diaryl heptanoids (1{"} 4) were evaluated for their inhibitory effects on NO production and downregulation of TNF-{\^I}± in RAW 264.7 macrophages and N-11 microglial cell lines).",

keywords = "Zingiberaceae, anti-inflammatory agents, diarylheptanoids, herbs, therapeutic use",

author = "Ritesh Raju and Ahilya Singh and Dhanushka Gunawardena and Paul Reddell and Gerald M{\"u}nch",

note = "Publisher Copyright: {\textcopyright} 2019 Phytochemical Society of Europe",

year = "2019",

month = apr,

doi = "10.1016/j.phytol.2019.01.004",

language = "English",

volume = "30",

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T1 - Diarylheptanoids with anti-inflammatory activity from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae)

AU - Raju, Ritesh

AU - Singh, Ahilya

AU - Gunawardena, Dhanushka

AU - Reddell, Paul

AU - Münch, Gerald

PY - 2019/4

Y1 - 2019/4

N2 - Three new metabolites, 1-(4"²"²-Methoxyphenyl)-7-(3"²,4"²-di-hydroxyphenyl)-(E)-hept-2-ene (1), 1-(4"²"²- Methoxyphenyl)-7-(3"²,4"²-di-methoxyphenyl)-(E)-hept-2-ene (2), 1-(4"²"²-Methoxyphenyl)-7-(4"²-methoxyphenyl)- (E)-hept-2-ene (3), and the known diaryl heptanoid (4) were identified following anti-inflammatory activity guided fractionation from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae). These diaryl heptanoids (1" 4) were evaluated for their inhibitory effects on NO production and downregulation of TNF-Î± in RAW 264.7 macrophages and N-11 microglial cell lines).

AB - Three new metabolites, 1-(4"²"²-Methoxyphenyl)-7-(3"²,4"²-di-hydroxyphenyl)-(E)-hept-2-ene (1), 1-(4"²"²- Methoxyphenyl)-7-(3"²,4"²-di-methoxyphenyl)-(E)-hept-2-ene (2), 1-(4"²"²-Methoxyphenyl)-7-(4"²-methoxyphenyl)- (E)-hept-2-ene (3), and the known diaryl heptanoid (4) were identified following anti-inflammatory activity guided fractionation from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae). These diaryl heptanoids (1" 4) were evaluated for their inhibitory effects on NO production and downregulation of TNF-Î± in RAW 264.7 macrophages and N-11 microglial cell lines).

KW - Zingiberaceae

KW - anti-inflammatory agents

KW - diarylheptanoids

KW - herbs

KW - therapeutic use

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:49456

U2 - 10.1016/j.phytol.2019.01.004

DO - 10.1016/j.phytol.2019.01.004

M3 - Article

SN - 1874-3900

VL - 30

SP - 10

EP - 13

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Diarylheptanoids with anti-inflammatory activity from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae)

Abstract

Bibliographical note

Keywords

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