Dietary manipulation for therapeutic effect in prostate cancer

Carol A. Gano, Kieran Scott, Joseph Bucci, Heather Greenfield, Qihan Dong, Paul L. de Souza

Research output: Chapter in Book / Conference PaperChapter

Abstract

Given that there is a wealth of literature on the potential effect of a wide variety of phytochemicals on the growth of prostate cancer cells, we have limited our discussion to arguably four of the most important: isoflavones, lycopene, resveratrol, and curcumin. The focus of this review is on the clinical pharmacology of these compounds, as there are already an extensive number of reviews in the literature on all of these compounds for various cancers, including our previous review of isoflavones in prostate cancer (de Souza et al., 2009). Here, we use the loose term “phytochemicals” to describe this group of plant–based compounds with biological activity in vitro, for simplicity. Like other phytochemicals, isoflavones, lycopene, resveratrol and curcumin have a wide variety of potential mechanisms of action in many different cancer cell lines. Many of these biological effects involve key components of signal transduction pathways within cancer cells, but in this review, we will be focusing on studies specifically in prostate cancer.
Original languageEnglish
Title of host publicationCancer Prevention: From Mechanisms to Translational Benefits
EditorsAlexandros Georgakilas
Place of PublicationCroatia
PublisherIn-Tech
Pages285-320
Number of pages36
ISBN (Print)9789535105473
DOIs
Publication statusPublished - 2012

Keywords

  • prostate cancer
  • phytochemicals
  • isoflavones
  • lycopene
  • resveratrol
  • curcumin

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