Differential effects of hydroxocobalamin on NO‐mediated relaxations in rat aorta and anococcygeus muscle

M. A.S. Rajanayagam; C. G. Li; M. J. Rand

doi:10.1111/j.1476-5381.1993.tb13429.x

Differential effects of hydroxocobalamin on NO‐mediated relaxations in rat aorta and anococcygeus muscle

M. A.S. Rajanayagam, C. G. Li, M. J. Rand

University of Melbourne

Research output: Contribution to journal › Article › peer-review

98 Citations (Scopus)

Abstract

In rat aortic rings, hydroxocobalamin (10–30 μm) produced concentration‐dependent reductions of the relaxant action of nitric oxide (NO) and the endothelium‐dependent, NO‐mediated, relaxant action of acetylcholine. In anococcygeus muscles, hydroxocobalamin (10–30 μm) reduced but also prolonged, NO‐induced relaxations, but had no effect on non‐adrenergic, non‐cholinergic‐mediated relaxations. Hydroxocobalamin had no effect on the NO‐independent relaxant action of papaverine in either tissue. It is suggested that hydroxocobalamin sequesters NO by forming nitrosocobalamin. Nitrosocobalamin did not relax aortic rings, but produced a slowly developing and prolonged relaxation of anococcygeus muscles. 1993 British Pharmacological Society

Original language	English
Pages (from-to)	3-5
Number of pages	3
Journal	British Journal of Pharmacology
Volume	108
Issue number	1
DOIs	https://doi.org/10.1111/j.1476-5381.1993.tb13429.x
Publication status	Published - Jan 1993
Externally published	Yes

Keywords

anococcygeus muscle
Aortic rings (rat)
endothelium‐dependent relaxation
hydroxocobalamin
nitrergic transmission
nitric oxide
nitrosocobalamin

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10.1111/j.1476-5381.1993.tb13429.x

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title = "Differential effects of hydroxocobalamin on NO‐mediated relaxations in rat aorta and anococcygeus muscle",

abstract = "In rat aortic rings, hydroxocobalamin (10–30 μm) produced concentration‐dependent reductions of the relaxant action of nitric oxide (NO) and the endothelium‐dependent, NO‐mediated, relaxant action of acetylcholine. In anococcygeus muscles, hydroxocobalamin (10–30 μm) reduced but also prolonged, NO‐induced relaxations, but had no effect on non‐adrenergic, non‐cholinergic‐mediated relaxations. Hydroxocobalamin had no effect on the NO‐independent relaxant action of papaverine in either tissue. It is suggested that hydroxocobalamin sequesters NO by forming nitrosocobalamin. Nitrosocobalamin did not relax aortic rings, but produced a slowly developing and prolonged relaxation of anococcygeus muscles. 1993 British Pharmacological Society",

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AU - Rand, M. J.

PY - 1993/1

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Differential effects of hydroxocobalamin on NO‐mediated relaxations in rat aorta and anococcygeus muscle

Abstract

Keywords

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