Diffuse melanosis cutis in the setting of BRAFV 600E metastatic melanoma

Deshan F. Sebaratnam, Linda K. Martin, Supriya S. Venugopal, George Mangos, John Freiman, Paul de Souza, Annabelle Farnsworth, Karen Cheung, Richard A. Scolyer, Dedee F. Murrell

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Case Report: A 79-year-old Caucasian male presented with a 1-week history of diffuse progressive blue-gray discoloration of the skin subsequently found to due to diffuse melanosis cutis (DMC) in the setting of metastatic melanoma. Mutation testing demonstrated BRAFV 600E mutation status, an unexpected finding given his age. He died two weeks after presentation. Discussion: As our understanding of the molecular subtypes of melanoma increases, in the future it may be possible to predict which melanoma patients have a predilection to developing DMC. Mutation testing of DMC patients should be considered as BRAF inhibitors, and other novel targeted therapies may improve the bleak prognosis associated with this unusual presentation of metastatic melanoma.
    Original languageEnglish
    Pages (from-to)1409-1411
    Number of pages3
    JournalInternational Journal of Dermatology
    Volume53
    Issue number11
    DOIs
    Publication statusPublished - 2014

    Keywords

    • hemoglobin
    • immunohistochemistry
    • melanins
    • melanosis
    • pathology

    Fingerprint

    Dive into the research topics of 'Diffuse melanosis cutis in the setting of BRAFV 600E metastatic melanoma'. Together they form a unique fingerprint.

    Cite this