Abstract
Secretion of the lysosomal enzyme hexosaminidase induced by zymosan is inhibited by mannose and by high concentrations of mannose-6-phosphate and 2-deoxy-glucose but not by mannan. Secretion of hexosaminidase from cells storing previously endocytosed zymosan is unaffected by mannose. Exposure of the cells to mannose does not affect secretion caused by subsequent exposure to zymosan. These findings suggest a role for the mannose-glycoprotein receptor in initiation of lysosomal enzyme secretion by zymosan.
| Original language | English |
|---|---|
| Pages (from-to) | 192-198 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 113 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 31 May 1983 |
| Externally published | Yes |
Fingerprint
Dive into the research topics of 'Does the induction of macrophage lysosomal enzyme secretion by zymosan involve the mannose receptor?'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver