TY - JOUR
T1 - Drug-delivery study and estimation of polymer-solvent interaction parameter for bisacrylate ester-modified Pluronic hydrogels
AU - Mawad, Damia
AU - Foster, John L. J. R.
AU - Lauto, Antonio
PY - 2008
Y1 - 2008
N2 - In this study, Pluronic F127 hydrogels were characterised as an injectable system for the controlled release of drugs with variable molecular weights (FITC-Dextran at 70 and 40 kDa). In addition, the polymer-solvent interaction parameter (χ) was successfully estimated. Pluronic hydrogels (10-25 wt.%) were redox cured and their swelling behaviour investigated in PBS (pH 7.45) at 37 ðC. After swelling to equilibrium, the hydrogels were compressed and the rubber-elasticity theory was applied to evaluate χ. Tensile tests proved the hydrogels were elastic and their χ values ranged between 0.50 and 0.53. The full drug load could be delivered over a period of ∼15 h suggesting that redox cured Pluronic F127 hydrogels can function as injectable systems for controlled and sustained release of macromolecules.
AB - In this study, Pluronic F127 hydrogels were characterised as an injectable system for the controlled release of drugs with variable molecular weights (FITC-Dextran at 70 and 40 kDa). In addition, the polymer-solvent interaction parameter (χ) was successfully estimated. Pluronic hydrogels (10-25 wt.%) were redox cured and their swelling behaviour investigated in PBS (pH 7.45) at 37 ðC. After swelling to equilibrium, the hydrogels were compressed and the rubber-elasticity theory was applied to evaluate χ. Tensile tests proved the hydrogels were elastic and their χ values ranged between 0.50 and 0.53. The full drug load could be delivered over a period of ∼15 h suggesting that redox cured Pluronic F127 hydrogels can function as injectable systems for controlled and sustained release of macromolecules.
UR - http://handle.uws.edu.au:8081/1959.7/553857
U2 - 10.1016/j.ijpharm.2008.04.032
DO - 10.1016/j.ijpharm.2008.04.032
M3 - Article
SN - 0378-5173
VL - 360
SP - 231
EP - 235
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 45323
ER -