TY - JOUR
T1 - Duration of estrogen exposure during reproductive years, age at menarche and age at menopause, and risk of cardiovascular disease events, all‐cause and cardiovascular mortality
T2 - a systematic review and meta‐analysis
AU - Mishra, SR
AU - Chung, H‐F
AU - Waller, M
AU - Mishra, GD
N1 - Publisher Copyright:
© 2020 John Wiley & Sons Ltd
PY - 2021/4
Y1 - 2021/4
N2 - Background: Little is known about the estrogen exposure measurement and mutual effect of age at menarche and age at menopause in the risk of cardiovascular disease (CVD) events. Objectives: To evaluate estrogen exposure measurement and describe mutual effect of age at menarche and age at menopause in the risk of CVD events. Search strategy: Systematic review of literature in PubMed, Embase and Web of Science for studies published up to 28 June 2020. Selection criteria: Observational studies related to estrogen exposure measurement, including mutual effect of age at menarche and age at menopause and risk of CVD events. Data collection and analysis: Synthesis of evidence was conducted by reviewing individual estimates, followed by meta-analysis. The study received no external funding. Main results: A total of 75 studies were included in synthesis of evidence, of which 17 studies were included in meta-analysis. Reproductive lifespan (age at menopause – age at menarche), endogenous estrogen exposure and total estrogen exposure were used for estrogen exposure measurement. Reproductive lifespan was by far the most commonly used method for estrogen exposure measurement. A shorter reproductive lifespan was associated with a higher risk of CVD events; the pooled relative risk (95% CI) was 1.31 (1.25–1.36) for stroke events. Robust epidemiological studies with measurement of estrogen exposure and associated health risk would strengthen the evidence. Conclusions: Reproductive lifespan was the most commonly used method for estrogen exposure measurement in epidemiological studies. A shorter reproductive lifespan was associated with a higher risk of CVD events, particularly stroke. Tweetable abstract: A systematic review and meta-analysis found that women with a shorter reproductive lifespan have a higher risk of stroke events.
AB - Background: Little is known about the estrogen exposure measurement and mutual effect of age at menarche and age at menopause in the risk of cardiovascular disease (CVD) events. Objectives: To evaluate estrogen exposure measurement and describe mutual effect of age at menarche and age at menopause in the risk of CVD events. Search strategy: Systematic review of literature in PubMed, Embase and Web of Science for studies published up to 28 June 2020. Selection criteria: Observational studies related to estrogen exposure measurement, including mutual effect of age at menarche and age at menopause and risk of CVD events. Data collection and analysis: Synthesis of evidence was conducted by reviewing individual estimates, followed by meta-analysis. The study received no external funding. Main results: A total of 75 studies were included in synthesis of evidence, of which 17 studies were included in meta-analysis. Reproductive lifespan (age at menopause – age at menarche), endogenous estrogen exposure and total estrogen exposure were used for estrogen exposure measurement. Reproductive lifespan was by far the most commonly used method for estrogen exposure measurement. A shorter reproductive lifespan was associated with a higher risk of CVD events; the pooled relative risk (95% CI) was 1.31 (1.25–1.36) for stroke events. Robust epidemiological studies with measurement of estrogen exposure and associated health risk would strengthen the evidence. Conclusions: Reproductive lifespan was the most commonly used method for estrogen exposure measurement in epidemiological studies. A shorter reproductive lifespan was associated with a higher risk of CVD events, particularly stroke. Tweetable abstract: A systematic review and meta-analysis found that women with a shorter reproductive lifespan have a higher risk of stroke events.
UR - https://go.openathens.net/redirector/westernsydney.edu.au?url=https://doi.org/10.1111/1471-0528.16524
U2 - 10.1111/1471-0528.16524
DO - 10.1111/1471-0528.16524
M3 - Article
C2 - 32965759
SN - 1470-0328
VL - 128
SP - 809
EP - 821
JO - BJOG: an International Journal of Obstetrics and Gynaecology
JF - BJOG: an International Journal of Obstetrics and Gynaecology
IS - 5
ER -
