Ecological and evolutionary consequences of anticancer adaptations

Justine Boutry; Antoine M. Dujon; Anne-Lise Gerard; Sophie Tissot; Nick Macdonald; Aaron Schultz; Peter A. Biro; Christa Beckmann; Rodrigo Hamede; David G. Hamilton; Mathieu Giraudeau; Beata Ujvari; Frederic Thomas

doi:10.1016/j.isci.2020.101716

Ecological and evolutionary consequences of anticancer adaptations

Justine Boutry, Antoine M. Dujon, Anne-Lise Gerard, Sophie Tissot, Nick Macdonald, Aaron Schultz, Peter A. Biro, Christa Beckmann, Rodrigo Hamede, David G. Hamilton, Mathieu Giraudeau, Beata Ujvari, Frederic Thomas

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research.

Original language	English
Article number	101716
Number of pages	13
Journal	iScience
Volume	23
Issue number	11
DOIs	https://doi.org/10.1016/j.isci.2020.101716
Publication status	Published - 2020

Open Access - Access Right Statement

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keywords

cancer
cells
ecology
evolution

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.isci.2020.101716

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title = "Ecological and evolutionary consequences of anticancer adaptations",

abstract = "Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research.",

keywords = "cancer, cells, ecology, evolution",

author = "Justine Boutry and Dujon, {Antoine M.} and Anne-Lise Gerard and Sophie Tissot and Nick Macdonald and Aaron Schultz and Biro, {Peter A.} and Christa Beckmann and Rodrigo Hamede and Hamilton, {David G.} and Mathieu Giraudeau and Beata Ujvari and Frederic Thomas",

year = "2020",

doi = "10.1016/j.isci.2020.101716",

language = "English",

volume = "23",

journal = "iScience",

issn = "2589-0042",

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TY - JOUR

T1 - Ecological and evolutionary consequences of anticancer adaptations

AU - Boutry, Justine

AU - Dujon, Antoine M.

AU - Gerard, Anne-Lise

AU - Tissot, Sophie

AU - Macdonald, Nick

AU - Schultz, Aaron

AU - Biro, Peter A.

AU - Beckmann, Christa

AU - Hamede, Rodrigo

AU - Hamilton, David G.

AU - Giraudeau, Mathieu

AU - Ujvari, Beata

AU - Thomas, Frederic

PY - 2020

Y1 - 2020

N2 - Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research.

AB - Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research.

KW - cancer

KW - cells

KW - ecology

KW - evolution

UR - https://hdl.handle.net/1959.7/uws:58525

U2 - 10.1016/j.isci.2020.101716

DO - 10.1016/j.isci.2020.101716

M3 - Article

SN - 2589-0042

VL - 23

JO - iScience

JF - iScience

IS - 11

M1 - 101716

ER -

Ecological and evolutionary consequences of anticancer adaptations

Abstract

Open Access - Access Right Statement

Keywords

UN SDGs

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