Effect of initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension on ambulatory blood pressure

J. M. Nolde; E. Atkins; S. Marschner; G. S. Hillis; J. Chalmers; L. Billot; M. R. Nelson; C. M. Reid; P. Hay; Michael Burke; S. Jansen; T. Usherwood; A. Rodgers; C. K. Chow; M. P. Schlaich

doi:10.1161/CIRCULATIONAHA.123.064964

Effect of initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension on ambulatory blood pressure

J. M. Nolde, E. Atkins, S. Marschner, G. S. Hillis, J. Chalmers, L. Billot, M. R. Nelson, C. M. Reid, P. Hay, Michael Burke, S. Jansen, T. Usherwood, A. Rodgers, C. K. Chow, M. P. Schlaich

Western Sydney University

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Hypertension management remains suboptimal globally, with treatment inertia being identified as one of the main barriers to achieving blood pressure (BP) control. Simpler approaches to achieve target BP levels are needed. The QUARTET study (Quadruple Ultra-Low-Dose Treatment for Hypertension) demonstrated that a single-pill combination of 4 BP-lowering medications at ultra-low (quarter) doses is more effective in reducing and maintaining lower unattended office BP than initial monotherapy with uptitration if needed. This Research Letter summarizes key, prespecified, secondary outcomes from 24-hour ambulatory BP monitoring (ABPM) performed at baseline and at 52 weeks of extended follow-up.

Original language	English
Pages (from-to)	375-377
Number of pages	3
Journal	Circulation
Volume	148
Issue number	4
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.123.064964
Publication status	Published - 2023

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Nolde, J. M., Atkins, E., Marschner, S., Hillis, G. S., Chalmers, J., Billot, L., Nelson, M. R., Reid, C. M., Hay, P., Burke, M., Jansen, S., Usherwood, T., Rodgers, A., Chow, C. K., & Schlaich, M. P. (2023). Effect of initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension on ambulatory blood pressure. Circulation, 148(4), 375-377. https://doi.org/10.1161/CIRCULATIONAHA.123.064964

@article{f3a2c0fec05349728a74a45082eaca66,

title = "Effect of initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension on ambulatory blood pressure",

abstract = "Hypertension management remains suboptimal globally, with treatment inertia being identified as one of the main barriers to achieving blood pressure (BP) control. Simpler approaches to achieve target BP levels are needed. The QUARTET study (Quadruple Ultra-Low-Dose Treatment for Hypertension) demonstrated that a single-pill combination of 4 BP-lowering medications at ultra-low (quarter) doses is more effective in reducing and maintaining lower unattended office BP than initial monotherapy with uptitration if needed. This Research Letter summarizes key, prespecified, secondary outcomes from 24-hour ambulatory BP monitoring (ABPM) performed at baseline and at 52 weeks of extended follow-up.",

author = "Nolde, {J. M.} and E. Atkins and S. Marschner and Hillis, {G. S.} and J. Chalmers and L. Billot and Nelson, {M. R.} and Reid, {C. M.} and P. Hay and Michael Burke and S. Jansen and T. Usherwood and A. Rodgers and Chow, {C. K.} and Schlaich, {M. P.}",

year = "2023",

doi = "10.1161/CIRCULATIONAHA.123.064964",

language = "English",

volume = "148",

pages = "375--377",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

Nolde, JM, Atkins, E, Marschner, S, Hillis, GS, Chalmers, J, Billot, L, Nelson, MR, Reid, CM, Hay, P, Burke, M, Jansen, S, Usherwood, T, Rodgers, A, Chow, CK & Schlaich, MP 2023, 'Effect of initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension on ambulatory blood pressure', Circulation, vol. 148, no. 4, pp. 375-377. https://doi.org/10.1161/CIRCULATIONAHA.123.064964

Effect of initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension on ambulatory blood pressure. / Nolde, J. M.; Atkins, E.; Marschner, S. et al.
In: Circulation, Vol. 148, No. 4, 2023, p. 375-377.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension on ambulatory blood pressure

AU - Nolde, J. M.

AU - Atkins, E.

AU - Marschner, S.

AU - Hillis, G. S.

AU - Chalmers, J.

AU - Billot, L.

AU - Nelson, M. R.

AU - Reid, C. M.

AU - Hay, P.

AU - Burke, Michael

AU - Jansen, S.

AU - Usherwood, T.

AU - Rodgers, A.

AU - Chow, C. K.

AU - Schlaich, M. P.

PY - 2023

Y1 - 2023

N2 - Hypertension management remains suboptimal globally, with treatment inertia being identified as one of the main barriers to achieving blood pressure (BP) control. Simpler approaches to achieve target BP levels are needed. The QUARTET study (Quadruple Ultra-Low-Dose Treatment for Hypertension) demonstrated that a single-pill combination of 4 BP-lowering medications at ultra-low (quarter) doses is more effective in reducing and maintaining lower unattended office BP than initial monotherapy with uptitration if needed. This Research Letter summarizes key, prespecified, secondary outcomes from 24-hour ambulatory BP monitoring (ABPM) performed at baseline and at 52 weeks of extended follow-up.

AB - Hypertension management remains suboptimal globally, with treatment inertia being identified as one of the main barriers to achieving blood pressure (BP) control. Simpler approaches to achieve target BP levels are needed. The QUARTET study (Quadruple Ultra-Low-Dose Treatment for Hypertension) demonstrated that a single-pill combination of 4 BP-lowering medications at ultra-low (quarter) doses is more effective in reducing and maintaining lower unattended office BP than initial monotherapy with uptitration if needed. This Research Letter summarizes key, prespecified, secondary outcomes from 24-hour ambulatory BP monitoring (ABPM) performed at baseline and at 52 weeks of extended follow-up.

UR - https://hdl.handle.net/1959.7/uws:74085

U2 - 10.1161/CIRCULATIONAHA.123.064964

DO - 10.1161/CIRCULATIONAHA.123.064964

M3 - Article

SN - 0009-7322

VL - 148

SP - 375

EP - 377

JO - Circulation

JF - Circulation

IS - 4

ER -

Effect of initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension on ambulatory blood pressure

Abstract

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