TY - JOUR
T1 - Effect of protein adsorption on hyaluronic acid/curcumin/multi-walled carbon nanotube based electrochemical sensor for detection of dopamine
AU - Xi, Weiyan
AU - Kong, Zimeng
AU - Zhang, Zhijia
AU - Chen, Yu
AU - Huang, Xuanyuan
AU - Deng, Zhaoxue
AU - Li, Zhen
AU - Xu, Xiaoxue
AU - Cui, Xiufang
AU - Zheng, Wei
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/9
Y1 - 2024/9
N2 - Resisting protein adsorption on electrode surfaces is one of pivotal challenges in the electrochemical analysis of small bioactive molecules. In this work, we constructed a novel electrochemical sensing electrode modified with hydrophilic hyaluronic acid (HA) and curcumin/multi-walled carbon nanotube (CM/MWCNTs). The modified electrodes were comprehensively characterized for dopamine detection including the sensing sensitivity, selectivity and stability. The constructed electrochemical sensor for dopamine detection exhibited remarkable resistance to protein adsorption because of the inherent hydrophilicity of HA, and synergistically, the superior electrochemical behavior of the CM/MWCNTs composite (quinone/hydroquinone redox couples enabled superior electrochemical behavior). The HA/CM/MWCNTs/GCE performed about 5.0 folds, 3.5 folds and 2.4 folds higher electrocatalytic current for dopamine than that revealed at bare GCE, MWCNTs/GCE, and CM/MWCNTs/GCE, respectively. In addition, the HA/CM/MWCNTs-based sensor demonstrated excellent sensing performance with a low detection limit of 0.009 μM (S/N = 3) within the concentration range from 50 to 200 μM. The constructed HA/CM/MWCNTs-modified glassy carbon electrodes offered a reliable platform for the real-time monitoring of dopamine with no protein absorption.
AB - Resisting protein adsorption on electrode surfaces is one of pivotal challenges in the electrochemical analysis of small bioactive molecules. In this work, we constructed a novel electrochemical sensing electrode modified with hydrophilic hyaluronic acid (HA) and curcumin/multi-walled carbon nanotube (CM/MWCNTs). The modified electrodes were comprehensively characterized for dopamine detection including the sensing sensitivity, selectivity and stability. The constructed electrochemical sensor for dopamine detection exhibited remarkable resistance to protein adsorption because of the inherent hydrophilicity of HA, and synergistically, the superior electrochemical behavior of the CM/MWCNTs composite (quinone/hydroquinone redox couples enabled superior electrochemical behavior). The HA/CM/MWCNTs/GCE performed about 5.0 folds, 3.5 folds and 2.4 folds higher electrocatalytic current for dopamine than that revealed at bare GCE, MWCNTs/GCE, and CM/MWCNTs/GCE, respectively. In addition, the HA/CM/MWCNTs-based sensor demonstrated excellent sensing performance with a low detection limit of 0.009 μM (S/N = 3) within the concentration range from 50 to 200 μM. The constructed HA/CM/MWCNTs-modified glassy carbon electrodes offered a reliable platform for the real-time monitoring of dopamine with no protein absorption.
KW - Anti-protein
KW - Dopamine
KW - Electrochemical sensor
KW - Nanocomposites
UR - http://www.scopus.com/inward/record.url?scp=85196721070&partnerID=8YFLogxK
U2 - 10.1016/j.inoche.2024.112763
DO - 10.1016/j.inoche.2024.112763
M3 - Article
AN - SCOPUS:85196721070
SN - 1387-7003
VL - 167
JO - Inorganic Chemistry Communications
JF - Inorganic Chemistry Communications
M1 - 112763
ER -