Efficacy of a topical wound agent methanesulfonic acid and dimethylsulfoxide on in vitro biofilms

Saskia Schwarzer, Michael Radzieta, Slade O. Jensen, Matthew Malone

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A topical desiccating wound agent containing methanesulfonic acid, dimethylsulfoxide and amorphous silica was evaluated in three in vitro models for its efficacy against biofilms produced by Pseudomonas aeruginosa (ATCC-15442) and Staphylococcus aureus (ATCC-6538). The in vitro biofilm models used were; the MBEC Assay®, Centre for Disease Control (CDC) Biofilm Reactor® and a Semi-solid biofilm model. A 30-s exposure of a topical wound desiccating agent was used in each model. A complete eradication of viable cells was demonstrated in all models for both strains (p < 0.0001). Imaging with scanning electron microscopy (SEM) was performed where possible. All three models demonstrated complete eradication of viable cells with a 30 s application of a topical wound desiccating agent.
Original languageEnglish
Article number9471
Number of pages10
JournalInternational Journal of Molecular Sciences
Volume22
Issue number17
Publication statusPublished - 2021

Open Access - Access Right Statement

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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