Efficacy of a topical wound agent methanesulfonic acid and dimethylsulfoxide on in vitro biofilms

Saskia Schwarzer; Michael Radzieta; Slade O. Jensen; Matthew Malone

doi:10.3390/ijms22179471

Efficacy of a topical wound agent methanesulfonic acid and dimethylsulfoxide on in vitro biofilms

Saskia Schwarzer
, Michael Radzieta
, Slade O. Jensen
, Matthew Malone

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A topical desiccating wound agent containing methanesulfonic acid, dimethylsulfoxide and amorphous silica was evaluated in three in vitro models for its efficacy against biofilms pro-duced by Pseudomonas aeruginosa (ATCC-15442) and Staphylococcus aureus (ATCC-6538). The in vitro biofilm models used were; the MBEC Assay®, Centre for Disease Control (CDC) Biofilm Reactor® and a Semi-solid biofilm model. A 30-s exposure of a topical wound desiccating agent was used in each model. A complete eradication of viable cells was demonstrated in all models for both strains (p < 0.0001). Imaging with scanning electron microscopy (SEM) was performed where possible. All three models demonstrated complete eradication of viable cells with a 30 s application of a topical wound desiccating agent.

Original language	English
Article number	9471
Number of pages	10
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	17
DOIs	https://doi.org/10.3390/ijms22179471
Publication status	Published - 1 Sept 2021

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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Open Access - Access Right Statement

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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title = "Efficacy of a topical wound agent methanesulfonic acid and dimethylsulfoxide on in vitro biofilms",

abstract = "A topical desiccating wound agent containing methanesulfonic acid, dimethylsulfoxide and amorphous silica was evaluated in three in vitro models for its efficacy against biofilms pro-duced by Pseudomonas aeruginosa (ATCC-15442) and Staphylococcus aureus (ATCC-6538). The in vitro biofilm models used were; the MBEC Assay{\textregistered}, Centre for Disease Control (CDC) Biofilm Reactor{\textregistered} and a Semi-solid biofilm model. A 30-s exposure of a topical wound desiccating agent was used in each model. A complete eradication of viable cells was demonstrated in all models for both strains (p < 0.0001). Imaging with scanning electron microscopy (SEM) was performed where possible. All three models demonstrated complete eradication of viable cells with a 30 s application of a topical wound desiccating agent.",

author = "Saskia Schwarzer and Michael Radzieta and Jensen, \{Slade O.\} and Matthew Malone",

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T1 - Efficacy of a topical wound agent methanesulfonic acid and dimethylsulfoxide on in vitro biofilms

AU - Schwarzer, Saskia

AU - Radzieta, Michael

AU - Jensen, Slade O.

AU - Malone, Matthew

PY - 2021/9/1

Y1 - 2021/9/1

N2 - A topical desiccating wound agent containing methanesulfonic acid, dimethylsulfoxide and amorphous silica was evaluated in three in vitro models for its efficacy against biofilms pro-duced by Pseudomonas aeruginosa (ATCC-15442) and Staphylococcus aureus (ATCC-6538). The in vitro biofilm models used were; the MBEC Assay®, Centre for Disease Control (CDC) Biofilm Reactor® and a Semi-solid biofilm model. A 30-s exposure of a topical wound desiccating agent was used in each model. A complete eradication of viable cells was demonstrated in all models for both strains (p < 0.0001). Imaging with scanning electron microscopy (SEM) was performed where possible. All three models demonstrated complete eradication of viable cells with a 30 s application of a topical wound desiccating agent.

AB - A topical desiccating wound agent containing methanesulfonic acid, dimethylsulfoxide and amorphous silica was evaluated in three in vitro models for its efficacy against biofilms pro-duced by Pseudomonas aeruginosa (ATCC-15442) and Staphylococcus aureus (ATCC-6538). The in vitro biofilm models used were; the MBEC Assay®, Centre for Disease Control (CDC) Biofilm Reactor® and a Semi-solid biofilm model. A 30-s exposure of a topical wound desiccating agent was used in each model. A complete eradication of viable cells was demonstrated in all models for both strains (p < 0.0001). Imaging with scanning electron microscopy (SEM) was performed where possible. All three models demonstrated complete eradication of viable cells with a 30 s application of a topical wound desiccating agent.

UR - http://hdl.handle.net/1959.7/uws:60852

U2 - 10.3390/ijms22179471

DO - 10.3390/ijms22179471

M3 - Article

C2 - 34502378

SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 17

M1 - 9471

ER -

Efficacy of a topical wound agent methanesulfonic acid and dimethylsulfoxide on in vitro biofilms

Abstract

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