Efficacy of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) : analysis of the Australian subpopulation of the TRUST study

Michael Boyer, Keith Horwood, Nick Pavlakis, Paul De Souza, Michael Millward, Brian Stein, Michael Johnston, Fiona Abell, Danny Rischin

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    5 Citations (Scopus)

    Abstract

    Aims: The efficacy of erlotinib (Tarceva, Roche Products, Dee Why, Australia) has been demonstrated in patients with advanced non-small-cell lung cancer (NSCLC). Tarceva lung cancer survival treatment (TRUST) is an open-label, single-arm, phase IV global trial which investigated erlotinib in advanced NSCLC patients who had failed prior therapy or were unsuitable for chemo/radiotherapy. The aim of this analysis was to report the safety and efficacy of erlotinib in the Australian patient subpopulation. Methods: Patients with stage IIIB/IV NSCLC progressing after standard systemic chemotherapy or unsuitable to receive chemo/radiotherapy were eligible for the study. The patients were treated with erlotinib at 150 mg/day orally, until disease progression or unacceptable toxicity. Results: In Australia, 460 patients were recruited. Erlotinib was given as first-line (16%), second-line (49%) or third-line (35%) treatment. In the intent-to-treat population (N = 460), the median progression-free survival was 2.7 months (95% CI 2.3–3.4), 1-year survival was 35% (95% CI 30–39%) and median overall survival was 6.9 months (95% CI 5.7–8.0). Tumor response rates were available for 363 patients, with a disease control rate of 58%. Of the 460 patients included in the safety analysis, 24% had one or more erlotinib-related adverse event (AE). Rash was reported in 77% of patients, most commonly grade ½ (63%). Treatment-related serious AE were reported in 7% of patients; most commonly diarrhea (2%). Dose modifications were required in 18% of patients. Conclusions: Outcomes for Australian patients confirmed the efficacy and tolerability of erlotinib for the treatment of advanced NSCLC in routine clinical practice.
    Original languageEnglish
    Pages (from-to)248-254
    Number of pages7
    JournalAsia-Pacific Journal of Clinical Oncology
    Volume8
    Issue number3
    Publication statusPublished - 2012

    Keywords

    • Australia
    • cancer
    • clinical trials
    • erlotinib
    • lungs
    • treatment

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