Efficient phosphine-mediated formal C(sp3)-C(sp3) coupling reactions of alkyl halides in batch and flow

U. P. N. Tran, K. J. Hock, C. P. Gordon, R. M. Koenigs, T. V. Nguyen

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The construction of C(sp3)–C(sp3) bond is an essential chemical transformation in synthetic chemistry due to its abundance in organic scaffolds. Here we demonstrate a valuable adaptation of the Wittig-type chemical procedure to efficiently facilitate C(sp3)–C(sp3) bond formation utilizing a range of alkyl building blocks. Additionally the method is amenable with flow synthesis to afford coupled products in good to excellent yields without laborious purification process.
Original languageEnglish
Pages (from-to)4950-4953
Number of pages4
JournalChemical Communications
Volume36
DOIs
Publication statusPublished - 2017

Keywords

  • chemicals
  • couplings
  • reactivity (chemistry)
  • transformation

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