Abstract
The construction of C(sp3)–C(sp3) bond is an essential chemical transformation in synthetic chemistry due to its abundance in organic scaffolds. Here we demonstrate a valuable adaptation of the Wittig-type chemical procedure to efficiently facilitate C(sp3)–C(sp3) bond formation utilizing a range of alkyl building blocks. Additionally the method is amenable with flow synthesis to afford coupled products in good to excellent yields without laborious purification process.
Original language | English |
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Pages (from-to) | 4950-4953 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 36 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- chemicals
- couplings
- reactivity (chemistry)
- transformation