Efficient phosphine-mediated formal C(sp3)-C(sp3) coupling reactions of alkyl halides in batch and flow

U. P. N. Tran; K. J. Hock; C. P. Gordon; R. M. Koenigs; T. V. Nguyen

doi:10.1039/c7cc02033c

Efficient phosphine-mediated formal C(sp3)-C(sp3) coupling reactions of alkyl halides in batch and flow

U. P. N. Tran, K. J. Hock, C. P. Gordon, R. M. Koenigs, T. V. Nguyen

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The construction of C(sp3)-C(sp3) bond is an essential chemical transformation in synthetic chemistry due to its abundance in organic scaffolds. Here we demonstrate a valuable adaptation of the Wittig-type chemical procedure to efficiently facilitate C(sp3)-C(sp3) bond formation utilizing a range of alkyl building blocks. Additionally the method is amenable with flow synthesis to afford coupled products in good to excellent yields without laborious purification process.

Original language	English
Pages (from-to)	4950-4953
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	36
DOIs	https://doi.org/10.1039/c7cc02033c
Publication status	Published - 2017

Bibliographical note

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

Keywords

chemicals
couplings
reactivity (chemistry)
transformation

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10.1039/c7cc02033c

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abstract = "The construction of C(sp3)-C(sp3) bond is an essential chemical transformation in synthetic chemistry due to its abundance in organic scaffolds. Here we demonstrate a valuable adaptation of the Wittig-type chemical procedure to efficiently facilitate C(sp3)-C(sp3) bond formation utilizing a range of alkyl building blocks. Additionally the method is amenable with flow synthesis to afford coupled products in good to excellent yields without laborious purification process.",

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AU - Tran, U. P. N.

AU - Hock, K. J.

AU - Gordon, C. P.

AU - Koenigs, R. M.

AU - Nguyen, T. V.

PY - 2017

Y1 - 2017

N2 - The construction of C(sp3)-C(sp3) bond is an essential chemical transformation in synthetic chemistry due to its abundance in organic scaffolds. Here we demonstrate a valuable adaptation of the Wittig-type chemical procedure to efficiently facilitate C(sp3)-C(sp3) bond formation utilizing a range of alkyl building blocks. Additionally the method is amenable with flow synthesis to afford coupled products in good to excellent yields without laborious purification process.

AB - The construction of C(sp3)-C(sp3) bond is an essential chemical transformation in synthetic chemistry due to its abundance in organic scaffolds. Here we demonstrate a valuable adaptation of the Wittig-type chemical procedure to efficiently facilitate C(sp3)-C(sp3) bond formation utilizing a range of alkyl building blocks. Additionally the method is amenable with flow synthesis to afford coupled products in good to excellent yields without laborious purification process.

KW - chemicals

KW - couplings

KW - reactivity (chemistry)

KW - transformation

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:40825

UR - http://www.scopus.com/inward/record.url?scp=85021631753&partnerID=8YFLogxK

U2 - 10.1039/c7cc02033c

DO - 10.1039/c7cc02033c

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SP - 4950

EP - 4953

JO - Chemical Communications

JF - Chemical Communications

IS - 36

ER -

Efficient phosphine-mediated formal C(sp3)-C(sp3) coupling reactions of alkyl halides in batch and flow

Abstract

Bibliographical note

Keywords

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